Thrombin-specific anticoagulation with bivalirudin versus heparin in patients receiving fibrinolytic therapy for acute myocardial infarction: the HERO-2 randomised trial

White, HD, Simes, RJ, Aylward, PEG, Armstrong, PW, Califf, RM, French, JK, Granger, CB, Marschner, IC, Topol, EJ, Van de Werf, FJ, Wilcox, RG, HERO-2 investigators and Strahan, Thomas M. (2001) Thrombin-specific anticoagulation with bivalirudin versus heparin in patients receiving fibrinolytic therapy for acute myocardial infarction: the HERO-2 randomised trial. Lancet, 358 9296: 1855-1863.

Author White, HD
Simes, RJ
Aylward, PEG
Armstrong, PW
Califf, RM
French, JK
Granger, CB
Marschner, IC
Topol, EJ
Van de Werf, FJ
Wilcox, RG
HERO-2 investigators
Strahan, Thomas M.
Title Thrombin-specific anticoagulation with bivalirudin versus heparin in patients receiving fibrinolytic therapy for acute myocardial infarction: the HERO-2 randomised trial
Journal name Lancet   Check publisher's open access policy
ISSN 0140-6736
Publication date 2001-12-01
Year available 2001
Sub-type Article (original research)
Open Access Status Not yet assessed
Volume 358
Issue 9296
Start page 1855
End page 1863
Total pages 9
Place of publication LONDON
Publisher LANCET LTD
Language eng
Abstract Background The combination of fibrinolytic therapy and heparin for acute myocardial infarction fails to achieve reperfusion in 40-70% of patients, and early reocclusion occurs in a substantial number. We did a randomised, open-label trial to compare the thrombin-specific anticoagulant, bivalirudin, with heparin in patients undergoing fibrinolysis with streptokinase for acute myocardial infarction.
Keyword Gusto-I Trial
Thrombolytic Therapy
Clinical Outcomes
Streptokinase
Inhibition
Predictors
Mortality
Aspirin
Hirulog
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: WoS Import - Archived
 
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