Human biomonitoring assessment values: approaches and data requirements

Angerer, Juergen, Aylward, Lesa L., Hays, Sean M., Heinzow, Birger and Wilhelm, Michael (2011) Human biomonitoring assessment values: approaches and data requirements. International Journal of Hygiene and Environmental Health, 214 5: 348-360. doi:10.1016/j.ijheh.2011.06.002

Author Angerer, Juergen
Aylward, Lesa L.
Hays, Sean M.
Heinzow, Birger
Wilhelm, Michael
Title Human biomonitoring assessment values: approaches and data requirements
Journal name International Journal of Hygiene and Environmental Health   Check publisher's open access policy
ISSN 1438-4639
Publication date 2011-09-01
Year available 2011
Sub-type Article (original research)
DOI 10.1016/j.ijheh.2011.06.002
Open Access Status Not yet assessed
Volume 214
Issue 5
Start page 348
End page 360
Total pages 13
Place of publication Muenchen, Germany
Publisher Elsevier GmbH - Urban und Fischer
Language eng
Abstract Human biomonitoring (HBM) data is a very useful metric for assessing human's exposures to chemicals in commerce. To assess the potential health risks associated with the presence of chemicals in blood, urine or other biological matrix requires HBM assessment values. While HBM assessment values based on human exposure-response data remain the most highly valuable and interpretable assessment values, enough data exists for such values for very few chemicals. As a consequence, efforts have been undertaken to derive HBM assessment values in which external dose based guidance values such as tolerable daily intakes have been translated into equivalent biomonitoring levels. The development of HBM values by the German HBM Commission and Biomonitoring Equivalents by Summit Toxicology has resulted in conceptually similar assessment values. The review of the development of these values provided here demonstrates examples and approaches that can be used to broaden the range of chemicals for which such assessment values can be derived. Efforts to date have resulted in the publication of HBM assessment values for more than 80 chemicals, and now provide tools that can be used for the evaluation of HBM data across chemicals and populations.
Keyword Biomonitoring
Biomonitoring equivalents
German Biomonitoring Commission
Risk assessment
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Pharmacy Publications
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