Biomonitoring Equivalents for interpretation of urinary fluoride

Aylward, L. L., Hays, S. M., Vezina, A., Deveau, M., St-Amand, A. and Nong, A. (2015) Biomonitoring Equivalents for interpretation of urinary fluoride. Regulatory Toxicology and Pharmacology, 72 1: 158-167. doi:10.1016/j.yrtph.2015.04.005

Author Aylward, L. L.
Hays, S. M.
Vezina, A.
Deveau, M.
St-Amand, A.
Nong, A.
Title Biomonitoring Equivalents for interpretation of urinary fluoride
Journal name Regulatory Toxicology and Pharmacology   Check publisher's open access policy
ISSN 1096-0295
Publication date 2015-06-01
Year available 2015
Sub-type Article (original research)
DOI 10.1016/j.yrtph.2015.04.005
Open Access Status Not Open Access
Volume 72
Issue 1
Start page 158
End page 167
Total pages 10
Place of publication Maryland Heights, MO United States
Publisher Academic Press
Language eng
Formatted abstract
Exposure to fluoride is widespread due to its natural occurrence in the environment and addition to drinking water and dental products for the prevention of dental caries. The potential health risks of excess fluoride exposure include aesthetically unacceptable dental fluorosis (tooth mottling) and increased skeletal fragility. Numerous organizations have conducted risk assessments and set guidance values to represent maximum recommended exposure levels as well as recommended adequate intake levels based on potential public health benefits of fluoride exposure. Biomonitoring Equivalents (BEs) are estimates of the average biomarker concentrations corresponding to such exposure guidance values. The literature on daily urinary fluoride excretion rates as a function of daily fluoride exposure was reviewed and BE values corresponding to the available US and Canadian exposure guidance values were derived for fluoride in urine. The derived BE values range from 1.1 to 2.1 mg/L (1.2–2.5 μg/g creatinine). Concentrations of fluoride in single urinary spot samples from individuals, even under exposure conditions consistent with the exposure guidance values, may vary from the predicted average concentrations by several-fold due to within- and across-individual variation in urinary flow and creatinine excretion rates and due to the rapid elimination kinetics of fluoride. Thus, the BE values are most appropriately applied to screen population central tendency estimates for biomarker concentrations rather than interpretation of individual spot sample concentrations.
Keyword Biomonitoring
Biomonitoring Equivalents
Risk assessment
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID 4500276415
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Non HERDC
National Research Centre for Environmental Toxicology Publications
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