Application of pharmacokinetic modelling for 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure assessment

Ruiz, P., Aylward, L. L. and Mumtaz, M. (2014) Application of pharmacokinetic modelling for 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure assessment. SAR and QSAR in Environmental Research, 25 11: 873-890. doi:10.1080/1062936X.2014.962083


Author Ruiz, P.
Aylward, L. L.
Mumtaz, M.
Title Application of pharmacokinetic modelling for 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure assessment
Formatted title
Application of pharmacokinetic modelling for 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure assessment
Journal name SAR and QSAR in Environmental Research   Check publisher's open access policy
ISSN 1029-046X
1062-936X
Publication date 2014-11-02
Year available 2014
Sub-type Article (original research)
DOI 10.1080/1062936X.2014.962083
Open Access Status Not yet assessed
Volume 25
Issue 11
Start page 873
End page 890
Total pages 18
Place of publication Abingdon, Oxfordshire, United Kingdom
Publisher Taylor and Francis
Language eng
Formatted abstract
Polychlorinated dibenzo-p-dioxins, polychlorinated dibenzofurans, and mono- and non-ortho polychlorinated biphenyls (dioxin-like PCBs) are identified as a family or group of organic compounds known as ‘dioxins’ or dioxin-like chemicals (DLCs). The most toxic member of this group is 2,3,7,8-tetrachlorodibenzo-(p)-dioxin (TCDD). Historically, DLCs have caused a variety of negative human health effects, but a disfiguring skin condition known as chloracne is the only health effect reported consistently. As part of translational research to make computerized models accessible to health risk assessors, the Concentration- and Age-Dependent Model (CADM) for TCDD was recoded in the Berkeley Madonna simulation language. The US Agency for Toxic Substances and Disease Registry’s computational toxicology laboratory used the recoded model to predict TCDD tissue concentrations at different exposure levels. The model simulations successfully reproduced the National Health and Nutrition Examination Survey (NHANES) 2001–2002 TCDD data in age groups from 6 to 60 years and older, as well as in other human datasets. The model also enabled the estimation of lipid-normalized serum TCDD concentrations in breastfed infants. The model performed best for low background exposures over time compared with a high acute poisoning case that could due to the large dose and associated liver toxicity. Hence, this model may be useful for interpreting human biomonitoring data as a part of an overall DLC risk assessment.
Keyword 2,3,7,8-tetrachlorodibenzo-p-dioxin
Dioxins
NHANES
PBPK
TCDD
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: National Research Centre for Environmental Toxicology Publications
 
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