Dioxin risks in perspective: past, present, and future

Hays, Sean M. and Aylward, Lesa L. (2003) Dioxin risks in perspective: past, present, and future. Regulatory Toxicology and Pharmacology, 37 2: 202-217. doi:10.1016/S0273-2300(02)00044-2

Author Hays, Sean M.
Aylward, Lesa L.
Title Dioxin risks in perspective: past, present, and future
Journal name Regulatory Toxicology and Pharmacology   Check publisher's open access policy
ISSN 0273-2300
Publication date 2003-04-01
Year available 2003
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/S0273-2300(02)00044-2
Open Access Status Not yet assessed
Volume 37
Issue 2
Start page 202
End page 217
Total pages 16
Place of publication Maryland Heights, MO, United States
Publisher Academic Press
Language eng
Abstract The United States Environmental Protection Agency (USEPA) and other U.S. and international agencies have focused extensive efforts on the evaluation of the potential health risks of exposures to chlorinated dioxins (PCDDs), furans (PCDFs), and related dioxin-like polychlorinated biphenyls (PCBs). Extensive regulatory efforts over the past 20 years have also been made to control emissions of these compounds and thus to reduce exposures in the general population. This paper reviews the available information on temporal trends in emissions, environmental levels, intake levels through foods, and human body burdens of dioxins. This paper also provides an overview and comparison of recent hazard assessments for dioxins from U.S. and international agencies. Available data on emissions, environmental and food levels, and human body burdens of dioxins in the general population indicate a several-fold reduction in exposures and body burdens in the general population over the three decades from 1970 to 2000. U.S. and international hazard assessments concur on certain aspects, but disagree on fundamental issues including the likelihood of a threshold for carcinogenic dose-response and the degree of safety factors needed in deriving a protective exposure limit. These disagreements have significant consequences for interpreting the potential health risks of current background dioxin exposure levels. However, whatever the degree of health risk that may be associated with current background exposures, the general population is experiencing several-fold lower exposures, and, therefore, lower health risks, currently compared to 30 years ago. In light of the dramatic declines in exposure already observed, further efforts to reduce exposures through attempts to control emissions or food levels should be carefully evaluated to understand the likely efficacy of the efforts and the relative costs and benefits.
Keyword Medicine, Legal
Pharmacology & Pharmacy
Legal Medicine
Pharmacology & Pharmacy
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: National Research Centre for Environmental Toxicology Publications
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Citation counts: TR Web of Science Citation Count  Cited 96 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 106 times in Scopus Article | Citations
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