Biomonitoring equivalents: a screening approach for interpreting biomonitoring results from a public health risk perspective

Hays, S. M., Becker, R. A., Leung, H. W., Aylward, L. L. and Pyatt, D. W. (2007) Biomonitoring equivalents: a screening approach for interpreting biomonitoring results from a public health risk perspective. Regulatory Toxicology and Pharmacology, 47 1: 96-109. doi:10.1016/j.yrtph.2006.08.004

Author Hays, S. M.
Becker, R. A.
Leung, H. W.
Aylward, L. L.
Pyatt, D. W.
Title Biomonitoring equivalents: a screening approach for interpreting biomonitoring results from a public health risk perspective
Journal name Regulatory Toxicology and Pharmacology   Check publisher's open access policy
ISSN 0273-2300
Publication date 2007-02-01
Year available 2006
Sub-type Article (original research)
DOI 10.1016/j.yrtph.2006.08.004
Open Access Status Not yet assessed
Volume 47
Issue 1
Start page 96
End page 109
Total pages 14
Place of publication Maryland Heights, MO, United States
Publisher Academic Press
Language eng
Abstract Advances in both sensitivity and specificity of analytical chemistry have made it possible to quantify substances in human biological specimens, such as blood, urine, and breast milk, in specimen volumes that are practical for collection from individuals. Research laboratories led by the Centers for Disease Control and Prevention (CDC) in its series National Report on Human Exposure to Environmental Chemicals [Centers for Disease Control and Prevention (CDC), 2005. Third National Report on Human Exposure to Environmental Chemicals. NCEH Pub. No. 05-0570.] are dedicating substantial resources to designing and conducting human biomonitoring studies and compiling biomonitoring data for the general population. However, the ability to quantitatively interpret the results of human biomonitoring in the context of a health risk assessment currently lags behind the analytical chemist's ability to make such measurements. The traditional paradigm for human health risk assessment of environmental chemicals involves comparing estimated daily doses to health-based criteria for acceptable, safe, or tolerable daily intakes (for example, reference doses [RfDs], tolerable daily intakes [TDIs], or minimal risk levels [MRLs]) to assess whether estimated doses exceed such health screening levels. However, biomonitoring efforts result in measured chemical concentrations in biological specimens (the result of absorption, distribution, metabolism and excretion of administered doses) rather than estimated intake doses. Quantitative benchmarks of acceptable or safe concentrations in biological specimens (analogous to RfDs, TDIs, or MRLs) needed to interpret these levels exist for very few chemicals of environmental interest. This paper discusses issues inherent in converting existing health screening benchmarks based on intake doses to screening levels for evaluating biomonitoring data, and presents methods and approaches that can be used to derive such screening levels (termed "Biomonitoring Equivalents," or BEs) for a range of chemicals and biological media.
Keyword Biomarkers
Exposure reconstruction
Risk assessment
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: National Research Centre for Environmental Toxicology Publications
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Citation counts: TR Web of Science Citation Count  Cited 120 times in Thomson Reuters Web of Science Article | Citations
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