Biomonitoring Equivalents for inorganic arsenic

Hays, Sean M., Aylward, Lesa L., Gagne, Michelle, Nong, Andy and Krishnan, Kannan (2010) Biomonitoring Equivalents for inorganic arsenic. Regulatory Toxicology and Pharmacology, 58 1: 1-9. doi:10.1016/j.yrtph.2010.06.002


Author Hays, Sean M.
Aylward, Lesa L.
Gagne, Michelle
Nong, Andy
Krishnan, Kannan
Title Biomonitoring Equivalents for inorganic arsenic
Journal name Regulatory Toxicology and Pharmacology   Check publisher's open access policy
ISSN 0273-2300
1096-0295
Publication date 2010-10-01
Sub-type Article (original research)
DOI 10.1016/j.yrtph.2010.06.002
Open Access Status Not yet assessed
Volume 58
Issue 1
Start page 1
End page 9
Total pages 9
Place of publication Maryland Heights, MO, United States
Publisher Academic Press
Language eng
Abstract This paper presents Biomonitoring Equivalents (BEs) for inorganic arsenic. Biomonitoring Equivalents (BEs) are defined as the concentration or range of concentrations of a chemical or its metabolite in a biological medium (blood, urine, or other medium) that is consistent with an existing health-based exposure guideline, and are derived by integrating available data on pharmacokinetics with existing chemical risk assessments. This study reviews available health-based exposure guidance values for arsenic based on recent evaluations from the United States Environmental Protection Agency (US EPA), US Agency for Toxic Substances and Disease Registry (ATSDR) and Health Canada (HC). BE values corresponding to the Reference Dose (RfD) or risk-specific doses for cancer endpoints from these agencies were derived based on kinetic data (urinary excretion) from controlled dosing studies in humans. The BE values presented here provide estimates of the sum of inorganic arsenic-derived urinary biomarkers (inorganic arsenic, monomethylated arsenic, and dimethylated arsenic). The BE associated with the United States Environmental Protection Agency's Reference Dose and the Agency for Toxic Substances and Disease Registry's Minimal Risk Level is 6.4μg arsenic/L urine. The BEs associated with the various cancer risk assessments are significantly lower. These BE values may be used as screening tools for evaluation of biomonitoring data for inorganic arsenic in a public health risk context.
Keyword Biomonitoring Equivalents
Inorganic arsenic
Pharmacokinetics
Risk assessment
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: National Research Centre for Environmental Toxicology Publications
 
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