Channels underlying neuronal calcium-activated potassium currents

Sah, P and Faber, ESL (2002) Channels underlying neuronal calcium-activated potassium currents. Progress In Neurobiology, 66 5: 345-353. doi:10.1016/S0301-0082(02)00004-7

Author Sah, P
Faber, ESL
Title Channels underlying neuronal calcium-activated potassium currents
Journal name Progress In Neurobiology   Check publisher's open access policy
ISSN 0301-0082
Publication date 2002-01-01
Year available 2002
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/S0301-0082(02)00004-7
Open Access Status
Volume 66
Issue 5
Start page 345
End page 353
Total pages 9
Place of publication Oxford
Publisher Pergamon-elsevier Science Ltd
Language eng
Abstract In many cell types rises in cytosolic calcium, either due to influx from the extracellular space, or by release from an intracellular store activates calcium dependent potassium currents on the plasmalemma. In neurons, these currents are largely activated following calcium influx via voltage gated calcium channels active during the action potentials. Three types of these currents are known: I-c. I-AHP and I-sAHP. These currents can be distinguished by clear differences in their pharmacology and kinetics. Activation of these potassium currents modulates action potential time course and the repetitive firing properties of neurons. Single channel studies have identified two types of calcium-activated potassium channel which can also be separated on biophysical and pharmacological grounds and have been named BK and SK channels. It is now clear that BK channels underlie Ic whereas SK channels underlie I-AHP. The identity of the channels underlying I-sAHP are not known. In this review, we discuss the properties of the different types of calcium-activated potassium channels and the relationship between these channels and the macroscopic currents present in neurons. (C) 2002 Elsevier Science Ltd. All rights reserved.
Keyword Neurosciences
Ca2+-activated K+ Channel
Hippocampal Pyramidal Neurons
Action-potential Repolarization
Bis-quinolinium Cyclophanes
Adrenal Chromaffin Cells
Rat Vagal Motoneurons
Human T-lymphocytes
Slow Afterhyperpolarization
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown
Additional Notes This document is a journal review.

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Excellence in Research Australia (ERA) - Collection
Queensland Brain Institute Publications
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Citation counts: TR Web of Science Citation Count  Cited 324 times in Thomson Reuters Web of Science Article | Citations
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Created: Mon, 13 Aug 2007, 23:01:17 EST