The APC/C in female mammalian meiosis I

Homer, Hayden (2013) The APC/C in female mammalian meiosis I. Reproduction, 146 2: R61-R71. doi:10.1530/REP-13-0163

Author Homer, Hayden
Title The APC/C in female mammalian meiosis I
Journal name Reproduction   Check publisher's open access policy
ISSN 1470-1626
Publication date 2013-08-01
Year available 2013
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1530/REP-13-0163
Open Access Status Not yet assessed
Volume 146
Issue 2
Start page R61
End page R71
Total pages 11
Place of publication Bristol, United Kingdom
Publisher BioScientifica
Language eng
Formatted abstract
The anaphase-promoting complex or cyclosome (APC/C) orchestrates a meticulously controlled sequence of proteolytic events critical for proper cell cycle progression, the details of which have been most extensively elucidated during mitosis. It has become apparent, however, that the APC/C, particularly when acting in concert with its Cdh1 co-activator (APC/CCdh1), executes a staggeringly diverse repertoire of functions that extend its remit well outside the bounds of mitosis. Findings over the past decade have not only earmarked mammalian oocyte maturation as one such case in point but have also begun to reveal a complex pattern of APC/C regulation that underpins many of the oocyte's unique developmental attributes. This review will encompass the latest findings pertinent to the APC/C, especially APC/CCdh1, in mammalian oocytes and how its activity and substrates shape the stop-start tempo of female mammalian first meiotic division and the challenging requirement for assembling spindles in the absence of centrosomes.
Keyword Developmental Biology
Reproductive Biology
Developmental Biology
Reproductive Biology
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID 082587/Z/07/Z
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 15 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 16 times in Scopus Article | Citations
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