New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk

Lu, Yingchang, Day, Felix R., Gustafsson, Stefan, Buchkovich, Martin L., Na, Jianbo, Bataille, Veronique, Cousminer, Diana L., Dastani, Zari, Drong, Alexander W., Esko, Tonu, Evans, David M., Falchi, Mario, Feitosa, Mary F., Ferreira, Teresa, Hedman, Asa K., Haring, Robin, Hysi, Pirro G., Iles, Mark M., Justice, Anne E., Kanoni, Stavroula, Lagou, Vasiliki, Li, Rui, Li, Xin, Locke, Adam, Lu, Chen, Magi, Reedik, Perry, John R. B., Pers, Tune H., Qi, Qibin, Sanna, Marianna, Schmidt, Ellen M., Scott, William R., Shungin, Dmitry, Teumer, Alexander, Vinkhuyzen, Anna A. E., Walker, Ryan W., Westra, Harm-Jan, Zhang, Mingfeng, Zhang, Weihua, Zhao, Jing Hua, Zhu, Zhihong, Afzal, Uzma, Ahluwalia, Tarunveer Singh, Bakker, Stephan J. L., Bellis, Claire, Bonnefond, Amelie, Borodulin, Katja, Buchman, Aron S., Cederholm, Tommy, Choh, Audrey C., Choi, Hyung Jin, Curran, Joanne E., de Groot, Lisette C. P. G. M., De Jager, Philip L., Dhonukshe-Rutten, Rosalie A. M., Enneman, Anke W., Eury, Elodie, Evans, Daniel S., Forsen, Tom, Friedrich, Nele, Fumeron, Frederic, Garcia, Melissa E., Gartner, Simone, Han, Bok-Ghee, Havulinna, Aki S., Hayward, Caroline, Hernandez, Dena, Hillege, Hans, Ittermann, Till, Kent, Jack W., Kolcic, Ivana, Laatikainen, Tiina, Lahti, Jari, Leach, Irene Mateo, Lee, Christine G., Lee, Jong-Young, Liu, Tian, Liu, Youfang, Lobbens, Stephane, Loh, Marie, Lyytikainen, Leo-Pekka, Medina-Gomez, Carolina, Michaelsson, Karl, Nalls, Mike A., Nielson, Carrie M., Oozageer, Laticia, Pascoe, Laura, Paternoster, Lavinia, Polasek, Ozren, Ripatti, Samuli, Sarzynski, Mark A., Shin, Chan Soo, Narancic, Nina Smolej, Spira, Dominik, Srikanth, Priya, Steinhagen-Thiessen, Elisabeth, Sung, Yun Ju, Swart, Karin M. A., Taittonen, Leena, Tanaka, Toshiko, Tikkanen, Emmi, van der Velde, Nathalie, van Schoor, Natasja M., Verweij, Niek, Wright, Alan F., Yu, Lei, Zmuda, Joseph M., Eklund, Niina, Forrester, Terrence, Grarup, Niels, Jackson, Anne U., Kristiansson, Kati, Kuulasmaa, Teemu, Kuusisto, Johanna, Lichtner, Peter, Luan, Jian'an, Mahajan, Anubha, Mannisto, Satu, Palmer, Cameron D., Ried, Janina S., Scott, Robert A., Stancakova, Alena, Wagner, Peter J., Demirkan, Ayse, Doring, Angela, Gudnason, Vilmundur, Kiel, Douglas P., Kuhnel, Brigitte, Mangino, Massimo, Mcknight, Barbara, Menni, Cristina, O'Connell, Jeffrey R., Oostra, Ben A., Shuldiner, Alan R., Song, Kijoung, Vandenput, Liesbeth, van Duijn, Cornelia M., Vollenweider, Peter, White, Charles C., Boehnke, Michael, Boettcher, Yvonne, Cooper, Richard S., Forouhi, Nita G., Gieger, Christian, Grallert, Harald, Hingorani, Aroon, Jorgensen, Torben, Jousilahti, Pekka, Kivimaki, Mika, Kumari, Meena, Laakso, Markku, Langenberg, Claudia, Linneberg, Allan, Luke, Amy, Mckenzie, Colin A., Palotie, Aarno, Pedersen, Oluf, Peters, Annette, Strauch, Konstantin, Tayo, Bamidele O., Wareham, Nicholas J., Bennett, David A., Bertram, Lars, Blangero, John, Bluher, Matthias, Bouchard, Claude, Campbell, Harry, Cho, Nam H., Cummings, Steven R., Czerwinski, Stefan A., Demuth, Ilja, Eckardt, Rahel, Eriksson, Johan G., Ferrucci, Luigi, Franco, Oscar H., Froguel, Philippe, Gansevoort, Ron T., Hansen, Torben, Harris, Tamara B., Hastie, Nicholas, Heliovaara, Markku, Hofman, Albert, Jordan, Joanne M., Jula, Antti, Kahonen, Mika, Kajantie, Eero, Knekt, Paul B., Koskinen, Seppo, Kovacs, Peter, Lehtimaki, Terho, Lind, Lars, Liu, Yongmei, Orwoll, Eric S., Osmond, Clive, Perola, Markus, Perusse, Louis, Raitakari, Olli T., Rankinen, Tuomo, Rao, D. C., Rice, Treva K., Rivadeneira, Fernando, Rudan, Igor, Salomaa, Veikko, Sorensen, Thorkild I. A., Stumvoll, Michael, Tonjes, Anke, Towne, Bradford, Tranah, Gregory J., Tremblay, Angelo, Uitterlinden, Andre G., van der Harst, Pim, Vartiainen, Erkki, Viikari, Jorma S., Vitart, Veronique, Vohl, Marie-Claude, Volzke, Henry, Walker, Mark, Wallaschofski, Henri, Wild, Sarah, Wilson, James F., Yengo, Loic, Bishop, D. Timothy, Borecki, Ingrid B., Chambers, John C., Cupples, L. Adrienne, Dehghan, Abbas, Deloukas, Panos, Fatemifar, Ghazaleh, Fox, Caroline, Furey, Terrence S., Franke, Lude, Han, Jiali, Hunter, David J., Karjalainen, Juha, Karpe, Fredrik, Kaplan, Robert C., Kooner, Jaspal S., McCarthy, Mark I., Murabito, Joanne M., Morris, Andrew P., Bishop, Julia A. N., North, Kari E., Ohlsson, Claes, Ong, Ken K., Prokopenko, Inga, Richards, J. Brent, Schadt, Eric E., Spector, Tim D., Widen, Elisabeth, Willer, Cristen J., Yang, Jian, Ingelsson, Erik, Mohlke, Karen L., Hirschhorn, Joel N., Pospisilik, John Andrew, Zillikens, M. Carola, Lindgren, Cecilia, Kilpelainen, Tuomas Oskari and Loos, Ruth J. F. (2016) New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk. Nature Communications, 7 10495-10495. doi:10.1038/ncomms10495


Author Lu, Yingchang
Day, Felix R.
Gustafsson, Stefan
Buchkovich, Martin L.
Na, Jianbo
Bataille, Veronique
Cousminer, Diana L.
Dastani, Zari
Drong, Alexander W.
Esko, Tonu
Evans, David M.
Falchi, Mario
Feitosa, Mary F.
Ferreira, Teresa
Hedman, Asa K.
Haring, Robin
Hysi, Pirro G.
Iles, Mark M.
Justice, Anne E.
Kanoni, Stavroula
Lagou, Vasiliki
Li, Rui
Li, Xin
Locke, Adam
Lu, Chen
Magi, Reedik
Perry, John R. B.
Pers, Tune H.
Qi, Qibin
Sanna, Marianna
Schmidt, Ellen M.
Scott, William R.
Shungin, Dmitry
Teumer, Alexander
Vinkhuyzen, Anna A. E.
Walker, Ryan W.
Westra, Harm-Jan
Zhang, Mingfeng
Zhang, Weihua
Zhao, Jing Hua
Zhu, Zhihong
Afzal, Uzma
Ahluwalia, Tarunveer Singh
Bakker, Stephan J. L.
Bellis, Claire
Bonnefond, Amelie
Borodulin, Katja
Buchman, Aron S.
Cederholm, Tommy
Choh, Audrey C.
Choi, Hyung Jin
Curran, Joanne E.
de Groot, Lisette C. P. G. M.
De Jager, Philip L.
Dhonukshe-Rutten, Rosalie A. M.
Enneman, Anke W.
Eury, Elodie
Evans, Daniel S.
Forsen, Tom
Friedrich, Nele
Fumeron, Frederic
Garcia, Melissa E.
Gartner, Simone
Han, Bok-Ghee
Havulinna, Aki S.
Hayward, Caroline
Hernandez, Dena
Hillege, Hans
Ittermann, Till
Kent, Jack W.
Kolcic, Ivana
Laatikainen, Tiina
Lahti, Jari
Leach, Irene Mateo
Lee, Christine G.
Lee, Jong-Young
Liu, Tian
Liu, Youfang
Lobbens, Stephane
Loh, Marie
Lyytikainen, Leo-Pekka
Medina-Gomez, Carolina
Michaelsson, Karl
Nalls, Mike A.
Nielson, Carrie M.
Oozageer, Laticia
Pascoe, Laura
Paternoster, Lavinia
Polasek, Ozren
Ripatti, Samuli
Sarzynski, Mark A.
Shin, Chan Soo
Narancic, Nina Smolej
Spira, Dominik
Srikanth, Priya
Steinhagen-Thiessen, Elisabeth
Sung, Yun Ju
Swart, Karin M. A.
Taittonen, Leena
Tanaka, Toshiko
Tikkanen, Emmi
van der Velde, Nathalie
van Schoor, Natasja M.
Verweij, Niek
Wright, Alan F.
Yu, Lei
Zmuda, Joseph M.
Eklund, Niina
Forrester, Terrence
Grarup, Niels
Jackson, Anne U.
Kristiansson, Kati
Kuulasmaa, Teemu
Kuusisto, Johanna
Lichtner, Peter
Luan, Jian'an
Mahajan, Anubha
Mannisto, Satu
Palmer, Cameron D.
Ried, Janina S.
Scott, Robert A.
Stancakova, Alena
Wagner, Peter J.
Demirkan, Ayse
Doring, Angela
Gudnason, Vilmundur
Kiel, Douglas P.
Kuhnel, Brigitte
Mangino, Massimo
Mcknight, Barbara
Menni, Cristina
O'Connell, Jeffrey R.
Oostra, Ben A.
Shuldiner, Alan R.
Song, Kijoung
Vandenput, Liesbeth
van Duijn, Cornelia M.
Vollenweider, Peter
White, Charles C.
Boehnke, Michael
Boettcher, Yvonne
Cooper, Richard S.
Forouhi, Nita G.
Gieger, Christian
Grallert, Harald
Hingorani, Aroon
Jorgensen, Torben
Jousilahti, Pekka
Kivimaki, Mika
Kumari, Meena
Laakso, Markku
Langenberg, Claudia
Linneberg, Allan
Luke, Amy
Mckenzie, Colin A.
Palotie, Aarno
Pedersen, Oluf
Peters, Annette
Strauch, Konstantin
Tayo, Bamidele O.
Wareham, Nicholas J.
Bennett, David A.
Bertram, Lars
Blangero, John
Bluher, Matthias
Bouchard, Claude
Campbell, Harry
Cho, Nam H.
Cummings, Steven R.
Czerwinski, Stefan A.
Demuth, Ilja
Eckardt, Rahel
Eriksson, Johan G.
Ferrucci, Luigi
Franco, Oscar H.
Froguel, Philippe
Gansevoort, Ron T.
Hansen, Torben
Harris, Tamara B.
Hastie, Nicholas
Heliovaara, Markku
Hofman, Albert
Jordan, Joanne M.
Jula, Antti
Kahonen, Mika
Kajantie, Eero
Knekt, Paul B.
Koskinen, Seppo
Kovacs, Peter
Lehtimaki, Terho
Lind, Lars
Liu, Yongmei
Orwoll, Eric S.
Osmond, Clive
Perola, Markus
Perusse, Louis
Raitakari, Olli T.
Rankinen, Tuomo
Rao, D. C.
Rice, Treva K.
Rivadeneira, Fernando
Rudan, Igor
Salomaa, Veikko
Sorensen, Thorkild I. A.
Stumvoll, Michael
Tonjes, Anke
Towne, Bradford
Tranah, Gregory J.
Tremblay, Angelo
Uitterlinden, Andre G.
van der Harst, Pim
Vartiainen, Erkki
Viikari, Jorma S.
Vitart, Veronique
Vohl, Marie-Claude
Volzke, Henry
Walker, Mark
Wallaschofski, Henri
Wild, Sarah
Wilson, James F.
Yengo, Loic
Bishop, D. Timothy
Borecki, Ingrid B.
Chambers, John C.
Cupples, L. Adrienne
Dehghan, Abbas
Deloukas, Panos
Fatemifar, Ghazaleh
Fox, Caroline
Furey, Terrence S.
Franke, Lude
Han, Jiali
Hunter, David J.
Karjalainen, Juha
Karpe, Fredrik
Kaplan, Robert C.
Kooner, Jaspal S.
McCarthy, Mark I.
Murabito, Joanne M.
Morris, Andrew P.
Bishop, Julia A. N.
North, Kari E.
Ohlsson, Claes
Ong, Ken K.
Prokopenko, Inga
Richards, J. Brent
Schadt, Eric E.
Spector, Tim D.
Widen, Elisabeth
Willer, Cristen J.
Yang, Jian
Ingelsson, Erik
Mohlke, Karen L.
Hirschhorn, Joel N.
Pospisilik, John Andrew
Zillikens, M. Carola
Lindgren, Cecilia
Kilpelainen, Tuomas Oskari
Loos, Ruth J. F.
Title New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk
Journal name Nature Communications   Check publisher's open access policy
ISSN 2041-1723
Publication date 2016-02-01
Year available 2016
Sub-type Article (original research)
DOI 10.1038/ncomms10495
Open Access Status DOI
Volume 7
Start page 10495
End page 10495
Total pages 15
Place of publication London, United Kingdom
Publisher Nature Publishing Group
Language eng
Subject 1600 Chemistry
1300 Biochemistry, Genetics and Molecular Biology
3100 Physics and Astronomy
Abstract To increase our understanding of the genetic basis of adiposity and its links to cardiometabolic disease risk, we conducted a genome-wide association meta-analysis of body fat percentage (BF%) in up to 100,716 individuals. Twelve loci reached genome-wide significance (P<5 × 10(-8)), of which eight were previously associated with increased overall adiposity (BMI, BF%) and four (in or near COBLL1/GRB14, IGF2BP1, PLA2G6, CRTC1) were novel associations with BF%. Seven loci showed a larger effect on BF% than on BMI, suggestive of a primary association with adiposity, while five loci showed larger effects on BMI than on BF%, suggesting association with both fat and lean mass. In particular, the loci more strongly associated with BF% showed distinct cross-phenotype association signatures with a range of cardiometabolic traits revealing new insights in the link between adiposity and disease risk.
Formatted abstract
To increase our understanding of the genetic basis of adiposity and its links to cardiometabolic disease risk, we conducted a genome-wide association meta-analysis of body fat percentage (BF%) in up to 100,716 individuals. Twelve loci reached genome-wide significance (P<5 × 10−8), of which eight were previously associated with increased overall adiposity (BMI, BF%) and four (in or near COBLL1/GRB14, IGF2BP1, PLA2G6, CRTC1) were novel associations with BF%. Seven loci showed a larger effect on BF% than on BMI, suggestive of a primary association with adiposity, while five loci showed larger effects on BMI than on BF%, suggesting association with both fat and lean mass. In particular, the loci more strongly associated with BF% showed distinct cross-phenotype association signatures with a range of cardiometabolic traits revealing new insights in the link between adiposity and disease risk.
Keyword Genome-wide association
Mass index
Insulin resistance
Common variants
Genetic architecture
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID MC_UP_A100_1003
R01 DK106236
R01 DK072193
P30 DK079637
MR/J012165/1
R01 DK075787
MC_UU_12015/1
MC_U106179471
K01 HL129892
MC_UU_12015/2
MR/J010642/1
P30 AG010161
MC_U106179472
IK2 CX000729
P30 DK020541
MC_UU_12013/4
MC_PC_U127561128
U01 DK062370
R01 DK089256
K01 AR062655
MR/K006584/1
MR/K013351/1
281641
P30 DK020572
MC_UU_12015/5
MC_UU_12011/4
R01 HL117078
10589
Institutional Status UQ
Additional Notes Article # 10495

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
Queensland Brain Institute Publications
UQ Diamantina Institute Publications
 
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