Formaldehyde stress responses in bacterial pathogens

Chen, Nathan H., Djoko, Karrera Y., Veyrier, Frédéric J. and McEwan, Alastair G. (2016) Formaldehyde stress responses in bacterial pathogens. Frontiers in Microbiology, 7 MAR: 257.1-257.17. doi:10.3389/fmicb.2016.00257

Author Chen, Nathan H.
Djoko, Karrera Y.
Veyrier, Frédéric J.
McEwan, Alastair G.
Title Formaldehyde stress responses in bacterial pathogens
Journal name Frontiers in Microbiology   Check publisher's open access policy
ISSN 1664-302X
Publication date 2016-03-03
Sub-type Article (original research)
DOI 10.3389/fmicb.2016.00257
Open Access Status DOI
Volume 7
Issue MAR
Start page 257.1
End page 257.17
Total pages 17
Place of publication Lausanne, Switzerland
Publisher Frontiers Research Foundation
Language eng
Abstract Formaldehyde is the simplest of all aldehydes and is highly cytotoxic. Its use and associated dangers from environmental exposure have been well documented. Detoxification systems for formaldehyde are found throughout the biological world and they are especially important in methylotrophic bacteria, which generate this compound as part of their metabolism of methanol. Formaldehyde metabolizing systems can be divided into those dependent upon pterin cofactors, sugar phosphates and those dependent upon glutathione. The more prevalent thiol-dependent formaldehyde detoxification system is found in many bacterial pathogens, almost all of which do not metabolize methane or methanol. This review describes the endogenous and exogenous sources of formaldehyde, its toxic effects and mechanisms of detoxification. The methods of formaldehyde sensing are also described with a focus on the formaldehyde responsive transcription factors HxlR, FrmR, and NmlR. Finally, the physiological relevance of detoxification systems for formaldehyde in bacterial pathogens is discussed.
Keyword Haemophilus
Host–pathogen interactions
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
School of Chemistry and Molecular Biosciences
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Created: Fri, 18 Mar 2016, 22:25:07 EST by Mrs Louise Nimwegen on behalf of School of Chemistry & Molecular Biosciences