Insights into the biology and therapeutic applications of neural stem cells

Harris, Lachlan, Zalucki, Oressia, Piper, Michael and Heng, Julian Ik-Tsen (2016) Insights into the biology and therapeutic applications of neural stem cells. Stem Cells International, 2016 . doi:10.1155/2016/9745315


Author Harris, Lachlan
Zalucki, Oressia
Piper, Michael
Heng, Julian Ik-Tsen
Title Insights into the biology and therapeutic applications of neural stem cells
Journal name Stem Cells International   Check publisher's open access policy
ISSN 1687-9678
1687-966X
Publication date 2016-02-08
Year available 2016
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1155/2016/9745315
Open Access Status DOI
Volume 2016
Total pages 18
Place of publication New York, United States
Publisher Hindawi Publishing Corporation
Language eng
Formatted abstract
The cerebral cortex is essential for our higher cognitive functions and emotional reasoning. Arguably, this brain structure is the distinguishing feature of our species, and yet our remarkable cognitive capacity has seemingly come at a cost to the regenerative capacity of the human brain. Indeed, the capacity for regeneration and neurogenesis of the brains of vertebrates has declined over the course of evolution, from fish to rodents to primates. Nevertheless, recent evidence supporting the existence of neural stem cells (NSCs) in the adult human brain raises new questions about the biological significance of adult neurogenesis in relation to ageing and the possibility that such endogenous sources of NSCs might provide therapeutic options for the treatment of brain injury and disease. Here, we highlight recent insights and perspectives on NSCs within both the developing and adult cerebral cortex. Our review of NSCs during development focuses upon the diversity and therapeutic potential of these cells for use in cellular transplantation and in the modeling of neurodevelopmental disorders. Finally, we describe the cellular and molecular characteristics of NSCs within the adult brain and strategies to harness the therapeutic potential of these cell populations in the treatment of brain injury and disease.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: HERDC Pre-Audit
Queensland Brain Institute Publications
School of Biomedical Sciences Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 6 times in Thomson Reuters Web of Science Article | Citations
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Created: Fri, 18 Mar 2016, 18:41:15 EST by Dr Michael Piper on behalf of School of Biomedical Sciences