Melatonin suppresses nighttime memory formation in zebrafish

Rawashdeh, Oliver, de Borsetti, Nancy Hernandez, Roman, Gregg and Cahill, Gregory M. (2007) Melatonin suppresses nighttime memory formation in zebrafish. Science, 318 5853: 1144-1146. doi:10.1126/science.1148564

Author Rawashdeh, Oliver
de Borsetti, Nancy Hernandez
Roman, Gregg
Cahill, Gregory M.
Title Melatonin suppresses nighttime memory formation in zebrafish
Journal name Science   Check publisher's open access policy
ISSN 0036-8075
Publication date 2007-11-16
Year available 2007
Sub-type Article (original research)
DOI 10.1126/science.1148564
Open Access Status Not yet assessed
Volume 318
Issue 5853
Start page 1144
End page 1146
Total pages 3
Place of publication Washington, DC, United States
Publisher American Association for the Advancement of Science
Language eng
Abstract Memory processes are modulated by the biological clock, although the mechanisms are unknown. Here, we report that in the diurnal zebrafish both learning and memory formation of an operant conditioning paradigm occur better during the day than during the night. Melatonin treatment during the day mimics the nighttime suppression of memory formation. Training in constant light improves nighttime memory formation while reducing endogenous melatonin concentrations. Treatment with melatonin receptor antagonists at night dramatically improves memory. Pinealectomy also significantly improves nighttime memory formation. We adduce that melatonin is both sufficient and necessary for poor memory formation during the night.
Keyword Multidisciplinary Sciences
Science & Technology - Other Topics
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID MH60939
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Biomedical Sciences Publications
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Citation counts: TR Web of Science Citation Count  Cited 84 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 92 times in Scopus Article | Citations
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Created: Wed, 16 Mar 2016, 18:55:09 EST by Oliver Rawashdeh on behalf of Learning and Research Services (UQ Library)