Genetic influences on schizophrenia and subcortical brain volumes: large-scale proof of concept

Franke, Barbara, Stein, Jason L., Ripke, Stephan, Anttila, Verneri, Hibar, Derrek P., Van Hulzen, Kimm J. E., Arias-Vasquez, Alejandro, Smoller, Jordan W., Nichols, Thomas E., Neale, Michael C., McIntosh, Andrew M., Lee, Phil, McMahon, Francis J., Meyer-Lindenberg, Andreas, Mattheisen, Manuel, Andreassen, Ole A., Gruber, Oliver, Sachdev, Perminder S., Roiz-Santianez, Roberto, Saykin, Andrew J., Ehrlich, Stefan, Mather, Karen A., Turner, Jessica A., Schwarz, Emanuel, Thalamuthu, Anbupalam, Yao, Yin, Ho, Yvonne Y. W., Martin, Nicholas G., Wright, Margaret J., O'Donovan, Michael C., Thompson, Paul M., Neale, Benjamin M., Medland, Sarah E. and Sullivan, Patrick F. (2016) Genetic influences on schizophrenia and subcortical brain volumes: large-scale proof of concept. Nature Neuroscience, 19 3: 420-431. doi:10.1038/nn.4228

Author Franke, Barbara
Stein, Jason L.
Ripke, Stephan
Anttila, Verneri
Hibar, Derrek P.
Van Hulzen, Kimm J. E.
Arias-Vasquez, Alejandro
Smoller, Jordan W.
Nichols, Thomas E.
Neale, Michael C.
McIntosh, Andrew M.
Lee, Phil
McMahon, Francis J.
Meyer-Lindenberg, Andreas
Mattheisen, Manuel
Andreassen, Ole A.
Gruber, Oliver
Sachdev, Perminder S.
Roiz-Santianez, Roberto
Saykin, Andrew J.
Ehrlich, Stefan
Mather, Karen A.
Turner, Jessica A.
Schwarz, Emanuel
Thalamuthu, Anbupalam
Yao, Yin
Ho, Yvonne Y. W.
Martin, Nicholas G.
Wright, Margaret J.
O'Donovan, Michael C.
Thompson, Paul M.
Neale, Benjamin M.
Medland, Sarah E.
Sullivan, Patrick F.
Title Genetic influences on schizophrenia and subcortical brain volumes: large-scale proof of concept
Journal name Nature Neuroscience   Check publisher's open access policy
ISSN 1546-1726
Publication date 2016-03-01
Year available 2016
Sub-type Article (original research)
DOI 10.1038/nn.4228
Open Access Status Not Open Access
Volume 19
Issue 3
Start page 420
End page 431
Total pages 12
Place of publication New York, NY, United States
Publisher Nature Publishing Group
Language eng
Subject 2800 Neuroscience
Abstract Schizophrenia is a devastating psychiatric illness with high heritability. Brain structure and function differ, on average, between people with schizophrenia and healthy individuals. As common genetic associations are emerging for both schizophrenia and brain imaging phenotypes, we can now use genome-wide data to investigate genetic overlap. Here we integrated results from common variant studies of schizophrenia (33,636 cases, 43,008 controls) and volumes of several (mainly subcortical) brain structures (11,840 subjects). We did not find evidence of genetic overlap between schizophrenia risk and subcortical volume measures either at the level of common variant genetic architecture or for single genetic markers. These results provide a proof of concept (albeit based on a limited set of structural brain measures) and define a roadmap for future studies investigating the genetic covariance between structural or functional brain phenotypes and risk for psychiatric disorders.
Keyword Schizophrenia
Brain function
Brain structure
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID P50MH080272
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
School of Psychology Publications
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Citation counts: TR Web of Science Citation Count  Cited 48 times in Thomson Reuters Web of Science Article | Citations
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