Timing of routine infant vaccinations and risk of food allergy and eczema at one year of age

Kiraly, N., Koplin, J. J., Crawford, N. W., Bannister, S., Flanagan, K. L., Holt, P. G., Gurrin, L. C., Lowe, A. J., Tang, M. L. K., Wake, M., Ponsonby, A. -L., Dharmage, S. C. and Allen, K. J. (2016) Timing of routine infant vaccinations and risk of food allergy and eczema at one year of age. Allergy, 71 4: 541-549. doi:10.1111/all.12830


Author Kiraly, N.
Koplin, J. J.
Crawford, N. W.
Bannister, S.
Flanagan, K. L.
Holt, P. G.
Gurrin, L. C.
Lowe, A. J.
Tang, M. L. K.
Wake, M.
Ponsonby, A. -L.
Dharmage, S. C.
Allen, K. J.
Title Timing of routine infant vaccinations and risk of food allergy and eczema at one year of age
Journal name Allergy   Check publisher's open access policy
ISSN 1398-9995
0105-4538
Publication date 2016-04-01
Year available 2016
Sub-type Article (original research)
DOI 10.1111/all.12830
Open Access Status Not Open Access
Volume 71
Issue 4
Start page 541
End page 549
Total pages 9
Place of publication Chichester, West Sussex, United Kingdom
Publisher Wiley-Blackwell Publishing
Language eng
Formatted abstract
Background: Epidemiological evidence suggests that routine vaccinations can have nontargeted effects on susceptibility to infections and allergic disease. Such effects may depend on age at vaccination, and a delay in pertussis vaccination has been linked to reduced risk of allergic disease. We aimed to test the hypothesis that delay in vaccines containing diphtheria-tetanus-acellular pertussis (DTaP) is associated with reduced risk of food allergy and other allergic diseases.

Methods: HealthNuts is a population-based cohort in Melbourne, Australia. Twelve-month-old infants were skin prick-tested to common food allergens, and sensitized infants were offered oral food challenges to determine food allergy status. In this data linkage study, vaccination data for children in the HealthNuts cohort were obtained from the Australian Childhood Immunisation Register. Associations were examined between age at the first dose of DTaP and allergic disease.

Results: Of 4433 children, 109 (2.5%) received the first dose of DTaP one month late (delayed DTaP). Overall, delayed DTaP was not associated with primary outcomes of food allergy (adjusted odds ratio (aOR) 0.77; 95% CI: 0.36-1.62, P = 0.49) or atopic sensitization (aOR: 0.66; 95% CI: 0.35-1.24, P = 0.19). Amongst secondary outcomes, delayed DTaP was associated with reduced eczema (aOR: 0.57; 95% CI: 0.34-0.97, P = 0.04) and reduced use of eczema medication (aOR: 0.45; 95% CI: 0.24-0.83, P = 0.01).

Conclusions:
There was no overall association between delayed DTaP and food allergy; however, children with delayed DTaP had less eczema and less use of eczema medication. Timing of routine infant immunizations may affect susceptibility to allergic disease.
Keyword Atopic hypersensitivity
DTaP vaccine
Eczema
Food allergy
Infant
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
Child Health Research Centre Publications
 
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