ALDH1A1 provides a source of meiosis-inducing retinoic acid in mouse fetal ovaries

Bowles, Josephine, Feng, Chun-Wei, Miles, Kim, Ineson, Jessica, Spiller, Cassy and Koopman, Peter (2016) ALDH1A1 provides a source of meiosis-inducing retinoic acid in mouse fetal ovaries. Nature Communications, 7 10845.1-10845.8. doi:10.1038/ncomms10845


Author Bowles, Josephine
Feng, Chun-Wei
Miles, Kim
Ineson, Jessica
Spiller, Cassy
Koopman, Peter
Title ALDH1A1 provides a source of meiosis-inducing retinoic acid in mouse fetal ovaries
Journal name Nature Communications   Check publisher's open access policy
ISSN 2041-1723
Publication date 2016-02-19
Year available 2016
Sub-type Article (original research)
DOI 10.1038/ncomms10845
Open Access Status DOI
Volume 7
Start page 10845.1
End page 10845.8
Total pages 8
Place of publication London, United Kingdom
Publisher Nature Publishing
Language eng
Subject 1300 Biochemistry, Genetics and Molecular Biology
1600 Chemistry
3100 Physics and Astronomy
Abstract Substantial evidence exists that during fetal ovarian development in mammals, retinoic acid (RA) induces germ cells to express the pre-meiotic marker Stra8 and enter meiosis, and that these effects are prevented in the fetal testis by the RA-degrading P450 enzyme CYP26B1. Nonetheless, the role of RA has been disputed principally because germ cells in embryos lacking two major RA-synthesizing enzymes, ALDH1A2 and ALDH1A3, remain able to enter meiosis. Here we show that a third RA-synthesizing enzyme, ALDH1A1, is expressed in fetal ovaries, providing a likely source of RA in the absence of ALDH1A2 and ALDH1A3. In ovaries lacking ALDH1A1, the onset of germ cell meiosis is delayed. Our data resolve the conundrum posed by conflicting published data sets and reconfirm the model that meiosis is triggered by endogenous RA in the developing ovary.
Keyword Multidisciplinary Sciences
Science & Technology - Other Topics
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
Institute for Molecular Bioscience - Publications
 
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