Quantitative measurement of brain perfusion with intravoxel incoherent motion MR imaging

Federau, Christian, Maeder, Philippe, O'Brien, Kieran, Browaeys, Patrick, Meuli, Reto and Hagmann, Patric (2012) Quantitative measurement of brain perfusion with intravoxel incoherent motion MR imaging. Radiology, 265 3: 874-881. doi:10.1148/radiol.12120584

Author Federau, Christian
Maeder, Philippe
O'Brien, Kieran
Browaeys, Patrick
Meuli, Reto
Hagmann, Patric
Title Quantitative measurement of brain perfusion with intravoxel incoherent motion MR imaging
Journal name Radiology   Check publisher's open access policy
ISSN 0033-8419
Publication date 2012-12-01
Year available 2012
Sub-type Article (original research)
DOI 10.1148/radiol.12120584
Open Access Status Not yet assessed
Volume 265
Issue 3
Start page 874
End page 881
Total pages 8
Place of publication Oak Brook, IL United States
Publisher Radiological Society of North America
Language eng
Formatted abstract
To evaluate the sensitivity of the perfusion parameters derived from Intravoxel Incoherent Motion (IVIM) MR imaging to hypercapnia-induced vasodilatation and hyperoxygenation-induced vasoconstriction in the human brain.

Materials and Methods
This study was approved by the local ethics committee and informed consent was obtained from all participants. Images were acquired with a standard pulsed-gradient spin-echo sequence (Stejskal-Tanner) in a clinical 3-T system by using 16 b values ranging from 0 to 900 sec/mm2. Seven healthy volunteers were examined while they inhaled four different gas mixtures known to modify brain perfusion (pure oxygen, ambient air, 5% CO2 in ambient air, and 8% CO2 in ambient air). Diffusion coefficient (D), pseudodiffusion coefficient (D*), perfusion fraction (f), and blood flow–related parameter (fD*) maps were calculated on the basis of the IVIM biexponential model, and the parametric maps were compared among the four different gas mixtures. Paired, one-tailed Student t tests were performed to assess for statistically significant differences.

Signal decay curves were biexponential in the brain parenchyma of all volunteers. When compared with inhaled ambient air, the IVIM perfusion parameters D*, f, and fD* increased as the concentration of inhaled CO2 was increased (for the entire brain, P = .01 for f, D*, and fD* for CO2 5%; P = .02 for f, and P = .01 for D* and fD* for CO2 8%), and a trend toward a reduction was observed when participants inhaled pure oxygen (although P > .05). D remained globally stable.

The IVIM perfusion parameters were reactive to hyperoxygenation-induced vasoconstriction and hypercapnia-induced vasodilatation. Accordingly, IVIM imaging was found to be a valid and promising method to quantify brain perfusion in humans.
Keyword Radiology, Nuclear Medicine & Medical Imaging
Radiology, Nuclear Medicine & Medical Imaging
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Centre for Advanced Imaging Publications
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