Measuring brain perfusion with intravoxel incoherent motion (IVIM): initial clinical experience

Federau, Christian, O'Brien, Kieran, Meuli, Reto, Hagmann, Patric and Maeder, Philippe (2014) Measuring brain perfusion with intravoxel incoherent motion (IVIM): initial clinical experience. Journal of Magnetic Resonance Imaging, 39 3: 624-632. doi:10.1002/jmri.24195

Author Federau, Christian
O'Brien, Kieran
Meuli, Reto
Hagmann, Patric
Maeder, Philippe
Title Measuring brain perfusion with intravoxel incoherent motion (IVIM): initial clinical experience
Journal name Journal of Magnetic Resonance Imaging   Check publisher's open access policy
ISSN 1053-1807
Publication date 2014-03-01
Year available 2014
Sub-type Article (original research)
DOI 10.1002/jmri.24195
Open Access Status Not Open Access
Volume 39
Issue 3
Start page 624
End page 632
Total pages 9
Place of publication Hoboken, NJ United States
Publisher John Wiley & Sons
Language eng
Formatted abstract

To evaluate the feasibility of intravoxel incoherent motion (IVIM) perfusion measurements in the brain with currently available imaging systems.

Materials and Methods

We acquired high in-plane resolution (1.2 × 1.2 mm2) diffusion-weighted images with 16 different values of b ranging from 0 to 900 s/mm2, in three orthogonal directions, on 3T systems with a 32-multichannel receiver head coil. IVIM perfusion maps were extracted by fitting a double exponential model of signal amplitude decay. Regions of interest were drawn in pathological and control regions, where IVIM perfusion parameters were compared to the corresponding dynamic susceptibility contrast (DSC) parameters.


Hyperperfusion was found in the nonnecrotic or cystic part of two histologically proven glioblastoma multiforme and in two histologically proven glioma WHO grade III, as well as in a brain metastasis of lung adenocarcinoma, in a large meningioma, and in a case of ictal hyperperfusion. A monoexponential decay was found in a territory of acute ischemia, as well as in the necrotic part of a glioblastoma. The IVIM perfusion fraction f correlated well with DSC CBV.


Our initial report suggests that high-resolution brain perfusion imaging is feasible with IVIM in the current clinical setting.
Keyword Brain
Intravoxel incoherent motion (IVIM)
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Centre for Advanced Imaging Publications
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 62 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 63 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Sat, 05 Mar 2016, 00:31:01 EST by System User on behalf of Centre for Advanced Imaging