Development and performance evaluation of novel nanoparticles of a grafted copolymer loaded with curcumin

Mutalik, Srinivas, Suthar, Neelam A., Managuli, Renuka S., Shetty, Pallavi K., Avadhani, Kiran, Kalthur, Guruprasad, Kulkarni, Raghavendra V. and Thomas, Ranjeny (2016) Development and performance evaluation of novel nanoparticles of a grafted copolymer loaded with curcumin. International Journal of Biological Macromolecules, 86 709-720. doi:10.1016/j.ijbiomac.2015.11.092

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Author Mutalik, Srinivas
Suthar, Neelam A.
Managuli, Renuka S.
Shetty, Pallavi K.
Avadhani, Kiran
Kalthur, Guruprasad
Kulkarni, Raghavendra V.
Thomas, Ranjeny
Title Development and performance evaluation of novel nanoparticles of a grafted copolymer loaded with curcumin
Journal name International Journal of Biological Macromolecules   Check publisher's open access policy
ISSN 1879-0003
Publication date 2016-05-01
Year available 2016
Sub-type Article (original research)
DOI 10.1016/j.ijbiomac.2015.11.092
Open Access Status File (Author Post-print)
Volume 86
Start page 709
End page 720
Total pages 12
Place of publication Amsterdam, Netherlands
Publisher Elsevier
Language eng
Formatted abstract
Inflammatory bowel disease (IBD) is an inflammatory condition with mucosal ulceration, edema and hemorrhage of gastrointestinal tract. Curcumin has been shown to mitigate colitis in animal models. However, its usefulness is reduced due to poor pharmacokinetic behavior and low oral bioavailability. To address this, novel pH-sensitive hydrolyzed polyacrylamide-grafted-xanthan gum (PAAm-g-XG) nanoparticles (NPs) loaded with curcumin were prepared for colonic delivery. Optimized nanoparticles (CN20) were spherical, with an average size of 425 nm. A negligible amount of curcumin (≈8%) was released from CN20 NPs in pH 1.2 and 4.5 solutions. When the pH was increased to 7.2, curcumin release was comparatively faster than that observed with pH 1.2 and 4.5 collectively. In pH 6.8 solution, excellent release of curcumin was observed. Highest curcumin release was observed when rat caecal contents were incorporated in pH 6.8 solution, indicating microflora-dependent drug release property of NPs. In acetic acid-induced IBD in rats, curcumin NPs reduced myeloperoxidase and nitrite levels, prevented weight loss and attenuated colonic inflammation. Curcumin was better absorbed systemically in nanoparticulate form with increased Cmax (∼3 fold) and AUC (∼2.5 fold) than when delivered as free curcumin. We demonstrate successful development of grafted co-polymeric NPs containing drug suitable for colon targeting.
Keyword Grafted copolymer
Xanthan gum
Inflammatory bowel disease
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
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UQ Diamantina Institute Publications
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Citation counts: TR Web of Science Citation Count  Cited 6 times in Thomson Reuters Web of Science Article | Citations
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