Engineering pre-vascularized scaffolds for bone regeneration

Barabaschi, Giada D. G., Manoharan, Vijayan, Li, Qing and Bertassoni, Luiz E. (2015). Engineering pre-vascularized scaffolds for bone regeneration. In Luiz E. Bertassoni and Paulo G. Coelho (Ed.), Engineering mineralized and load bearing tissues (pp. 79-94) New York, NY, United States: Springer. doi:10.1007/978-3-319-22345-2_5

Author Barabaschi, Giada D. G.
Manoharan, Vijayan
Li, Qing
Bertassoni, Luiz E.
Title of chapter Engineering pre-vascularized scaffolds for bone regeneration
Title of book Engineering mineralized and load bearing tissues
Place of Publication New York, NY, United States
Publisher Springer
Publication Year 2015
Sub-type Research book chapter (original research)
DOI 10.1007/978-3-319-22345-2_5
Open Access Status Not Open Access
ISBN 9783319223445
ISSN 2214-8019
Editor Luiz E. Bertassoni
Paulo G. Coelho
Volume number 881
Start page 79
End page 94
Total pages 16
Total chapters 14
Language eng
Formatted Abstract/Summary
Survival of functional tissue constructs of clinically relevant size depends on the formation of an organized and uniformly distributed network of blood vessels and capillaries. The lack of such vasculature leads to spatio-temporal gradients in oxygen, nutrients and accumulation of waste products inside engineered tissue constructs resulting in negative biological events at the core of the scaffold. Unavailability of a well-defined vasculature also results in ineffective integration of scaffolds to the host vasculature upon implantation. Arguably, one of the greatest challenges in engineering clinically relevant bone substitutes, therefore, has been the development of vascularized bone scaffolds. Various approaches ranging from peptide and growth factor functionalized biomaterials to hyper-porous scaffolds have been proposed to address this problem with reasonable success. An emerging alternative to address this challenge has been the fabrication of pre-vascularized scaffolds by taking advantage of biomanufacturing techniques, such as soft- and photo-lithography or 3D bioprinting, and cell-based approaches, where functional capillaries are engineered in cell-laden scaffolds prior to implantation. These strategies seek to engineer pre-vascularized tissues in vitro, allowing for improved anastomosis with the host vasculature upon implantation, while also improving cell viability and tissue development in vitro. This book chapter provides an overview of recent methods to engineer pre-vascularized scaffolds for bone regeneration. We first review the development of functional blood capillaries in bony structures and discuss controlled delivery of growth factors, co-culture systems, and on-chip studies to engineer vascularized cell-laden biomaterials. Lastly, we review recent studies using microfabrication techniques and 3D printing to engineer pre-vascularized scaffolds for bone tissue engineering.
Keyword Angiogenesis
Bone regeneration
Bone scaffolds
Tissue engineering
Q-Index Code B1
Q-Index Status Provisional Code
Institutional Status Non-UQ

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