Organ-on-a-chip platforms for studying drug delivery systems

Bhise, Nupura S., Ribas, Joao, Manoharan, Vijayan, Zhang, Yu Shrike, Polini, Alessandro, Massa, Solange, Dokmeci, Mehmet R. and Khademhosseini, Ali (2014) Organ-on-a-chip platforms for studying drug delivery systems. Journal of Controlled Release, 190 82-93. doi:10.1016/j.jconrel.2014.05.004

Author Bhise, Nupura S.
Ribas, Joao
Manoharan, Vijayan
Zhang, Yu Shrike
Polini, Alessandro
Massa, Solange
Dokmeci, Mehmet R.
Khademhosseini, Ali
Title Organ-on-a-chip platforms for studying drug delivery systems
Journal name Journal of Controlled Release   Check publisher's open access policy
ISSN 1873-4995
Publication date 2014-09-28
Sub-type Article (original research)
DOI 10.1016/j.jconrel.2014.05.004
Open Access Status Not Open Access
Volume 190
Start page 82
End page 93
Total pages 12
Place of publication Amsterdam, Netherlands
Publisher Elsevier
Language eng
Abstract Novel microfluidic tools allow new ways to manufacture and test drug delivery systems. Organ-on-a-chip systems - microscale recapitulations of complex organ functions - promise to improve the drug development pipeline. This review highlights the importance of integrating microfluidic networks with 3D tissue engineered models to create organ-on-a-chip platforms, able to meet the demand of creating robust preclinical screening models. Specific examples are cited to demonstrate the use of these systems for studying the performance of drug delivery vectors and thereby reduce the discrepancies between their performance at preclinical and clinical trials. We also highlight the future directions that need to be pursued by the research community for these proof-of-concept studies to achieve the goal of accelerating clinical translation of drug delivery nanoparticles.
Keyword Organ-on-a-chip
Drug delivery
Drug screening
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Australian Institute for Bioengineering and Nanotechnology Publications
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Citation counts: TR Web of Science Citation Count  Cited 71 times in Thomson Reuters Web of Science Article | Citations
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Created: Fri, 26 Feb 2016, 21:00:45 EST by Anthony Yeates on behalf of Aust Institute for Bioengineering & Nanotechnology