The evolutionary dynamics of integrons in changing environments

Engelstadter, Jan, Harms, Klaus and Johnsen, Pal J. (2016) The evolutionary dynamics of integrons in changing environments. ISME Journal, 10 6: 1296-1307. doi:10.1038/ismej.2015.222


Author Engelstadter, Jan
Harms, Klaus
Johnsen, Pal J.
Title The evolutionary dynamics of integrons in changing environments
Journal name ISME Journal   Check publisher's open access policy
ISSN 1751-7370
1751-7362
Publication date 2016-02-05
Year available 2016
Sub-type Article (original research)
DOI 10.1038/ismej.2015.222
Open Access Status Not Open Access
Volume 10
Issue 6
Start page 1296
End page 1307
Total pages 12
Place of publication London, United Kingdom
Publisher Nature Publishing Group
Language eng
Subject 2404 Microbiology
1105 Ecology, Evolution, Behavior and Systematics
Abstract Integrons are genetic elements that are common in bacteria and are hotspots for genome evolution. They facilitate the acquisition and reassembly of gene cassettes encoding a variety of functions, including drug resistance. Despite their importance in clinical settings, the selective forces responsible for the evolution and maintenance of integrons are poorly understood. We present a mathematical model of integron evolution within bacterial populations subject to fluctuating antibiotic exposures. Bacteria carrying a functional integrase that mediates reshuffling of cassette genes and thereby modulates gene expression patterns compete with bacteria without a functional integrase. Our results indicate that for a wide range of parameters, the functional integrase can be stably maintained in the population despite substantial fitness costs. This selective advantage arises because gene-cassette shuffling generates genetic diversity, thus enabling the population to respond rapidly to changing selective pressures. We also show that horizontal gene transfer promotes stable maintenance of the integrase and can also lead to de novo assembly of integrons. Our model generates testable predictions for integron evolution, including loss of functional integrases in stable environments and selection for intermediate gene-shuffling rates in changing environments. Our results highlight the need for experimental studies of integron population biology.
Keyword Bacteria
Microorganisms
Drug resistance
Mobile genetic elements
Antibiotic resistance
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID FT140100907
204263
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
School of Biological Sciences Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 6 times in Thomson Reuters Web of Science Article | Citations
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