Potential influence of in utero and early neonatal exposures on the later development of endometriosis

Vannuccini, Silvia, Lazzeri, Lucia, Orlandini, Cinzia, Tosti, Claudia, Clifton, Vicki L. and Petraglia, Felice (2016) Potential influence of in utero and early neonatal exposures on the later development of endometriosis. Fertility and Sterility, 105 4: 997-1002. doi:10.1016/j.fertnstert.2015.12.127


Author Vannuccini, Silvia
Lazzeri, Lucia
Orlandini, Cinzia
Tosti, Claudia
Clifton, Vicki L.
Petraglia, Felice
Title Potential influence of in utero and early neonatal exposures on the later development of endometriosis
Journal name Fertility and Sterility   Check publisher's open access policy
ISSN 1556-5653
0015-0282
Publication date 2016-12-07
Sub-type Article (original research)
DOI 10.1016/j.fertnstert.2015.12.127
Open Access Status Not Open Access
Volume 105
Issue 4
Start page 997
End page 1002
Total pages 6
Place of publication Philadelphia, PA, United States
Publisher Elsevier
Collection year 2017
Language eng
Formatted abstract
Objective:  To investigate the possible correlation between maternal characteristics, in utero and early neonatal life exposures, and the development of endometriosis in adult life.

Design:  Case-control study.

Setting:  University hospital.

Patient(s):  A group of 161 patients with endometriosis and a control group of 230 women undergoing laparoscopy for benign adnexal diseases and free of endometriosis.

Intervention(s):  All women included in the study were requested to answer a series of questions about their mothers' gestational data and on their own perinatal and early postnatal lives.

Main Outcome Measure(s):  Odds ratio, adjusted odds ratios, and 95% confidence intervals for the associations between maternal characteristics during the patient's pregnancy, in utero exposure to obstetrical and perinatal complications, and the type of feeding received during the neonatal period with the development of endometriosis in adult life.

Result(s):  Mothers of women with endometriosis were significantly more likely to be affected by endometriosis or uterine fibroids, with a higher incidence of smoking during pregnancy. Women with endometriosis were more frequently born prematurely, with a significantly lower birth weight, and their mothers experienced preeclampsia during their pregnancies more often than control subjects. They were also more frequently formula fed than breast fed in early life. However, only prematurity and formula feeding were retained in the multivariate analysis model.

Conclusion(s):  Among intrauterine and early neonatal exposures, prematurity and formula feeding were risk factors for the development of endometriosis in adult life. Further studies should evaluate the underlying biologic mechanisms.
Keyword Endometriosis
Epigenetic
Formula feeding
Low birth weight
Preterm birth
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Mater Research Institute-UQ (MRI-UQ)
HERDC Pre-Audit
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 3 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 3 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Tue, 16 Feb 2016, 12:29:18 EST by System User on behalf of Learning and Research Services (UQ Library)