Cell-Free DNA as a Diagnostic Tool for Human Parasitic Infections

Weerakoon, Kosala G. and McManus, Donald P. (2016) Cell-Free DNA as a Diagnostic Tool for Human Parasitic Infections. Trends in Parasitology, 32 5: 378-391. doi:10.1016/j.pt.2016.01.006

Author Weerakoon, Kosala G.
McManus, Donald P.
Title Cell-Free DNA as a Diagnostic Tool for Human Parasitic Infections
Journal name Trends in Parasitology   Check publisher's open access policy
ISSN 1471-5007
Publication date 2016-05-01
Sub-type Article (original research)
DOI 10.1016/j.pt.2016.01.006
Open Access Status Not Open Access
Volume 32
Issue 5
Start page 378
End page 391
Total pages 14
Place of publication Kidlington, Oxford, United Kingdom
Publisher Elsevier
Language eng
Subject 2405 Parasitology
2725 Infectious Diseases
Abstract Parasites often cause devastating diseases and represent a significant public health and economic burden. More accurate and convenient diagnostic tools are needed in support of parasite control programmes in endemic regions, and for rapid point-of-care diagnosis in nonendemic areas. The detection of cell-free DNA (cfDNA) is a relatively new concept that is being applied in the current armamentarium of diagnostics. Here, we review the application of cfDNA detection with nucleic acid amplification tests for the diagnosis and evaluation of different human parasitic infections and highlight the significant benefits of the approach using non-invasive clinical samples.
Keyword Biomarkers
Cell free DNA
Nucleic acid amplification tests
Parasitic infections
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
School of Public Health Publications
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Citation counts: TR Web of Science Citation Count  Cited 6 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 11 times in Scopus Article | Citations
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