Diffusion magnetic resonance imaging study of schizophrenia in the context of abnormal neurodevelopment using multiple site data in a Chinese Han population

Li, Y., Xie, S., Liu, B., Song, M., Chen, Y., Li, P., Lu, L., Lv, L., Wang, H., Yan, H., Yan, J., Zhang, H., Zhang, D. and Jiang, T. (2016) Diffusion magnetic resonance imaging study of schizophrenia in the context of abnormal neurodevelopment using multiple site data in a Chinese Han population. Translational Psychiatry, 6 . doi:10.1038/tp.2015.202


Author Li, Y.
Xie, S.
Liu, B.
Song, M.
Chen, Y.
Li, P.
Lu, L.
Lv, L.
Wang, H.
Yan, H.
Yan, J.
Zhang, H.
Zhang, D.
Jiang, T.
Title Diffusion magnetic resonance imaging study of schizophrenia in the context of abnormal neurodevelopment using multiple site data in a Chinese Han population
Journal name Translational Psychiatry   Check publisher's open access policy
ISSN 2158-3188
Publication date 2016-01-19
Year available 2016
Sub-type Article (original research)
DOI 10.1038/tp.2015.202
Open Access Status DOI
Volume 6
Total pages 9
Place of publication London, United Kingdom
Publisher Nature Publishing Group
Language eng
Subject 2738 Psychiatry and Mental health
2804 Cellular and Molecular Neuroscience
2803 Biological Psychiatry
Abstract Schizophrenia has increasingly been considered a neurodevelopmental disorder, and the advancement of neuroimaging techniques and associated computational methods has enabled quantitative re-examination of this important theory on the pathogenesis of the disease. Inspired by previous findings from neonatal brains, we proposed that an increase in diffusion magnetic resonance imaging (dMRI) mean diffusivity (MD) should be observed in the cerebral cortex of schizophrenia patients compared with healthy controls, corresponding to lower tissue complexity and potentially a failure to reach cortical maturation. We tested this hypothesis using dMRI data from a Chinese Han population comprising patients from four different hospital sites. Utilizing data-driven methods based on the state-of-the-art tensor-based registration algorithm, significantly increased MD measurements were consistently observed in the cortex of schizophrenia patients across all four sites, despite differences in psychopathology, exposure to antipsychotic medication and scanners used for image acquisition. Specifically, we found increased MD in the limbic system of the schizophrenic brain, mainly involving the bilateral insular and prefrontal cortices. In light of the existing literature, we speculate that this may represent a neuroanatomical signature of the disorder, reflecting microstructural deficits due to developmental abnormalities. Our findings not only provide strong support to the abnormal neurodevelopment theory of schizophrenia, but also highlight an important neuroimaging endophenotype for monitoring the developmental trajectory of high-risk subjects of the disease, thereby facilitating early detection and prevention.
Keyword Independent component analysis
White matter abnormalities
Human cerebral cortex
Human brain
Discriminating schizophrenia
Rethinking schizophrenia
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
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Queensland Brain Institute Publications
 
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