Genome-wide genetic homogeneity between sexes and populations for human height and body mass index

Yang, Jian, Bakshi, Andrew, Zhu, Zhihong, Hemani, Gibran, Vinkhuyzen, Anna A. E., Nolte, Ilja M., van Vliet-Ostaptchouk, Jana V., Snieder, Harold, Study, Lifelines Cohort, Esko, Tonu, Milani, Lili, Maegi, Reedik, Metspalu, Andres, Hamsten, Anders, Magnusson, Patrik K. E., Pedersen, Nancy L., Ingelsson, Erik and Visscher, Peter M. (2015) Genome-wide genetic homogeneity between sexes and populations for human height and body mass index. Human Molecular Genetics, 24 25: 7445-7449. doi:10.1093/hmg/ddv443

Author Yang, Jian
Bakshi, Andrew
Zhu, Zhihong
Hemani, Gibran
Vinkhuyzen, Anna A. E.
Nolte, Ilja M.
van Vliet-Ostaptchouk, Jana V.
Snieder, Harold
Study, Lifelines Cohort
Esko, Tonu
Milani, Lili
Maegi, Reedik
Metspalu, Andres
Hamsten, Anders
Magnusson, Patrik K. E.
Pedersen, Nancy L.
Ingelsson, Erik
Visscher, Peter M.
Title Genome-wide genetic homogeneity between sexes and populations for human height and body mass index
Journal name Human Molecular Genetics   Check publisher's open access policy
ISSN 0964-6906
Publication date 2015-12-01
Year available 2015
Sub-type Article (original research)
DOI 10.1093/hmg/ddv443
Open Access Status Not Open Access
Volume 24
Issue 25
Start page 7445
End page 7449
Total pages 5
Place of publication Oxford, United Kingdom
Publisher Oxford University Press
Language eng
Subject 1312 Molecular Biology
1311 Genetics
2716 Genetics (clinical)
Abstract Sex-specific genetic effects have been proposed to be an important source of variation for human complex traits. Here we use two distinct genome-wide methods to estimate the autosomal genetic correlation (r(g)) between men and women for human height and body mass index (BMI), using individual-level (n = similar to 44 000) and summary-level (n = similar to 133 000) data from genome-wide association studies. Results are consistent and show that the between-sex genetic correlation is not significantly different from unity for both traits. In contrast, we find evidence of genetic heterogeneity between sexes for waist-hip ratio (r(g) = similar to 0.7) and between populations for BMI (r(g) = similar to 0.9 between Europe and the USA) but not for height. The lack of evidence for substantial genetic heterogeneity for body size is consistent with empirical findings across traits and species.
Keyword Sexual-Dimorphism
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID APP1078037
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
Official 2016 Collection
UQ Diamantina Institute Publications
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