Increased mortality for pregnancy-associated melanoma: systematic review and meta-analysis

Byrom, L., Olsen, C., Knight, L., Khosrotehrani, K. and Green, A. C. (2015) Increased mortality for pregnancy-associated melanoma: systematic review and meta-analysis. Journal of the European Academy of Dermatology and Venereology, 29 8: 1457-1466. doi:10.1111/jdv.12972

Author Byrom, L.
Olsen, C.
Knight, L.
Khosrotehrani, K.
Green, A. C.
Title Increased mortality for pregnancy-associated melanoma: systematic review and meta-analysis
Journal name Journal of the European Academy of Dermatology and Venereology   Check publisher's open access policy
ISSN 1468-3083
Publication date 2015-08-01
Sub-type Article (original research)
DOI 10.1111/jdv.12972
Open Access Status Not Open Access
Volume 29
Issue 8
Start page 1457
End page 1466
Total pages 10
Place of publication West Sussex, United Kingdom
Publisher Blackwell Publishing
Language eng
Formatted abstract
Among women, pregnancy-associated melanomas may have a poorer prognosis than other melanomas, but evidence is inconsistent. We conducted a systematic review and meta-analysis to assess the effect on melanoma outcome of a coinciding pregnancy. The objective of the study was to conduct a systematic review and meta-analysis of risk of death from, or recurrence of, pregnancy-associated melanomas compared with other melanomas in women of reproductive age. Cochrane (1996–2013), MEDLINE (1950–2013), EMBASE (1966–2013), CINAHL (1982–2013), and PUBMED (1951–2013) databases were searched for studies assessing the risk of death and recurrence in pregnancy-associated melanomas. Eligible studies investigated melanoma outcomes in women with pregnancy-associated melanomas (diagnosed during pregnancy or in 12 months following pregnancy), included a comparison group and reported measures of risk of melanoma death or disease-free survival. Eligible study designs were cohort studies of women of childbearing age with confirmed diagnoses of cutaneous melanoma. Individual study effect estimates were pooled using the weighted average method. Studies that did not report a quantitative estimate were summarized narratively. Of 304 citations identified, 14 studies met the inclusion criteria, with assessed outcomes being melanoma death (7), recurrence (3), or both (4). Pooled estimates of mortality risk from four studies showed increased risk of melanoma death after adjustment for patient age and stage of melanoma (pHR 1.56, 95% CI 1.23–1.99) for pregnancy-associated melanoma compared with other melanomas. Based on limited quantitative evidence, pregnancy-associated melanomas appear to have poorer outcomes than other melanomas.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: UQ Centre for Clinical Research Publications
Official 2016 Collection
UQ Diamantina Institute Publications
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 15 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 18 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Thu, 11 Feb 2016, 22:28:05 EST by Roheen Gill on behalf of Learning and Research Services (UQ Library)