The contribution of twins to the study of cognitive ageing and dementia: the Older Australian Twins Study

Sachdev, Perminder S., Lee, Teresa, Wen, Wei, Ames, David, Batouli, Amir H., Bowden, Jocelyn, Brodaty, Henry, Chong, Elizabeth, Crawford, John, Kang, Kristan, Mather, Karen, Lammel, Andrea, Slavin, Melissa J., Thalamuthu, Anbupalam, Trollor, Julian and Wright, Margie J. (2013) The contribution of twins to the study of cognitive ageing and dementia: the Older Australian Twins Study. International Review of Psychiatry, 25 6: 738-747. doi:10.3109/09540261.2013.870137


Author Sachdev, Perminder S.
Lee, Teresa
Wen, Wei
Ames, David
Batouli, Amir H.
Bowden, Jocelyn
Brodaty, Henry
Chong, Elizabeth
Crawford, John
Kang, Kristan
Mather, Karen
Lammel, Andrea
Slavin, Melissa J.
Thalamuthu, Anbupalam
Trollor, Julian
Wright, Margie J.
Title The contribution of twins to the study of cognitive ageing and dementia: the Older Australian Twins Study
Journal name International Review of Psychiatry   Check publisher's open access policy
ISSN 0954-0261
1369-1627
Publication date 2013-01-01
Sub-type Article (original research)
DOI 10.3109/09540261.2013.870137
Open Access Status Not yet assessed
Volume 25
Issue 6
Start page 738
End page 747
Total pages 10
Place of publication Abingdon, Oxfordshire United Kingdom
Publisher Taylor & Francis
Language eng
Abstract The Older Australian Twins Study (OATS) is a major longitudinal study of twins, aged ≥ 65 years, to investigate genetic and environmental factors and their interactions in healthy brain ageing and neurocognitive disorders. The study collects psychiatric, neuropsychological, cardiovascular, metabolic, biochemical, neuroimaging, genomic and proteomic data, with two-yearly assessments, and is currently in its third wave. The initial cohort comprises 623 individuals (161 monozygotic and 124 dizygotic twin pairs; 1 MZ triplets; 27 single twins and 23 non-twin siblings), of whom 426 have had wave 2 assessment. A number of salient findings have emerged thus far which assist in the understanding of genetic contributions to cognitive functions such as processing speed, executive ability and episodic memory, and which support the brain reserve hypothesis. The heritability of brain structures, both cortical and subcortical, brain spectroscopic metabolites and markers of small vessel disease, such as lacunar infarction and white matter hyperintensities, have been examined and can inform future genetic investigations. Work on amyloid imaging and functional magnetic resonance imaging is proceeding and epigenetic studies are progressing. This internationally important study has the potential to inform research into cognitive ageing in the future, and offers an excellent resource for collaborative work.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Queensland Brain Institute Publications
 
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