Meta-analysis of telomere length in 19 713 subjects reveals high heritability, stronger maternal inheritance and a paternal age effect

Broer, Linda, Codd, Veryan, Nyholt, Dale R., Deelen, Joris, Mangino, Massimo, Willemsen, Gonneke, Albrecht, Eva, Amin, Najaf, Beekman, Marian, de Geus, Eco J. C., Henders, Anjali, Nelson, Christopher P., Steves, Claire J., Wright, Margie J., de Craen, Anton J. M., Isaacs, Aaron, Matthews, Mary, Moayyeri, Alireza, Montgomery, Grant W., Oostra, Ben A., Vink, Jacqueline M., Spector, Tim D., Slagboom, P. Eline, Martin, Nicholas G., Samani, Nilesh J., van Duijn, Cornelia M. and Boomsma, Dorret I. (2013) Meta-analysis of telomere length in 19 713 subjects reveals high heritability, stronger maternal inheritance and a paternal age effect. European Journal of Human Genetics, 21 10: 1163-1168. doi:10.1038/ejhg.2012.303


Author Broer, Linda
Codd, Veryan
Nyholt, Dale R.
Deelen, Joris
Mangino, Massimo
Willemsen, Gonneke
Albrecht, Eva
Amin, Najaf
Beekman, Marian
de Geus, Eco J. C.
Henders, Anjali
Nelson, Christopher P.
Steves, Claire J.
Wright, Margie J.
de Craen, Anton J. M.
Isaacs, Aaron
Matthews, Mary
Moayyeri, Alireza
Montgomery, Grant W.
Oostra, Ben A.
Vink, Jacqueline M.
Spector, Tim D.
Slagboom, P. Eline
Martin, Nicholas G.
Samani, Nilesh J.
van Duijn, Cornelia M.
Boomsma, Dorret I.
Title Meta-analysis of telomere length in 19 713 subjects reveals high heritability, stronger maternal inheritance and a paternal age effect
Journal name European Journal of Human Genetics   Check publisher's open access policy
ISSN 1018-4813
1476-5438
Publication date 2013-01-01
Year available 2013
Sub-type Article (original research)
DOI 10.1038/ejhg.2012.303
Open Access Status Not yet assessed
Volume 21
Issue 10
Start page 1163
End page 1168
Total pages 6
Place of publication London, United Kingdom
Publisher Nature Publishing Group
Language eng
Abstract Telomere length (TL) has been associated with aging and mortality, but individual differences are also influenced by genetic factors, with previous studies reporting heritability estimates ranging from 34 to 82%. Here we investigate the heritability, mode of inheritance and the influence of parental age at birth on TL in six large, independent cohort studies with a total of 19 713 participants. The meta-analysis estimate of TL heritability was 0.70 (95% CI 0.64-0.76) and is based on a pattern of results that is highly similar for twins and other family members. We observed a stronger mother-offspring (r = 0.42; P-value = 3.60 x 10(-61)) than father-offspring correlation (r = 0.33; P-value = 7.01 x 10(-5)), and a significant positive association with paternal age at offspring birth (beta = 0.005; P-value = 7.01 x 10(-5)). Interestingly, a significant and quite substantial correlation in TL between spouses (r = 0.25; P-value = 2.82 x 10(-30)) was seen, which appeared stronger in older spouse pairs (mean age >= 55 years; r = 0.31; P-value = 4.27 x 10(-23)) than in younger pairs (mean age <55 years; r = 0.20; P-value = 3.24 x 10(-10)). In summary, we find a high and very consistent heritability estimate for TL, evidence for a maternal inheritance component and a positive association with paternal age.
Formatted abstract
Telomere length (TL) has been associated with aging and mortality, but individual differences are also influenced by genetic factors, with previous studies reporting heritability estimates ranging from 34 to 82%. Here we investigate the heritability, mode of inheritance and the influence of parental age at birth on TL in six large, independent cohort studies with a total of 19 713 participants. The meta-analysis estimate of TL heritability was 0.70 (95% CI 0.64-0.76) and is based on a pattern of results that is highly similar for twins and other family members. We observed a stronger mother-offspring (r=0.42; P-value=3.60 × 10 -61) than father-offspring correlation (r=0.33; P-value=7.01 × 10 -5), and a significant positive association with paternal age at offspring birth (β=0.005; P-value=7.01 × 10 -5). Interestingly, a significant and quite substantial correlation in TL between spouses (r=0.25; P-value=2.82 × 10 -30) was seen, which appeared stronger in older spouse pairs (mean age ≥55 years; r=0.31; P-value=4.27 × 10 -23) than in younger pairs (mean age<55 years; r=0.20; P-value=3.24 × 10 -10). In summary, we find a high and very consistent heritability estimate for TL, evidence for a maternal inheritance component and a positive association with paternal age.
Keyword Telomere length
Heritability
Paternal age effect
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID HEALTH-F4-2007-201413
259679
SenterNovem IGE05007
050-060-810
904-61-090
2008.024
184.021.007
HEALTH-F4-2007-201413
ERC-230374
496739
619667
FT0991022
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Queensland Brain Institute Publications
 
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