Dynamic iris changes as a risk factor in primary angle closure disease

Zhang, Ye, Li, Si Zhen, Li, Lei, He, Ming Guang, Thomas, Ravi and Wang, Ning Li (2016) Dynamic iris changes as a risk factor in primary angle closure disease. Investigative Ophthalmology and Visual Science, 57 1: 218-226. doi:10.1167/iovs.15-17651

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Author Zhang, Ye
Li, Si Zhen
Li, Lei
He, Ming Guang
Thomas, Ravi
Wang, Ning Li
Title Dynamic iris changes as a risk factor in primary angle closure disease
Journal name Investigative Ophthalmology and Visual Science   Check publisher's open access policy
ISSN 1552-5783
Publication date 2016-01-01
Sub-type Article (original research)
DOI 10.1167/iovs.15-17651
Open Access Status File (Publisher version)
Volume 57
Issue 1
Start page 218
End page 226
Total pages 9
Place of publication Rockville, MD, United States
Publisher Association for Research in Vision and Ophthalmology
Language eng
Formatted abstract
Purpose: We studied the association between dynamic iris changes and the spectrum of primary angle closure disease (PACD), using the anterior segment optical coherence tomography (ASOCT).

Methods: Eligible primary angle closure (PAC), primary angle closure glaucoma (PACG), age, and sex comparable primary angle closure suspects (PACS) and normal subjects from the 5-year follow-up of the Handan Eye Study underwent ASOCT testing in dark and light conditions. The right eye of each subject was analyzed and biometric parameters including iris cross-sectional area (IA), lens vault (LV), pupil diameter (PD), and centroid-to-centroid distance (CCD) were calculated using the Zhongshan Angle Assessment Program.

Results: Totals of 31 PACS, 31 PAC/PACG, and 31 normal eyes were eligible for analysis. Loss of IA per mm PD increase in the dark compared to light was 0.18 mm in PACS, 0.13 mm in PAC/PACG, and 0.24 mm in normal (P = 0.015 between groups) groups. Diagnoses of normal (P = 0.001) and a smaller PD in light (P = 0.003) were statistically significant determinants of a larger IA loss per mm PD increase in the dark compared to light. Logistic regression analysis showed that LV (P = 0.002) and IA loss per mm PD increase (P = 0.017) were risk factors for an occludable angle.

Conclusions: Significant differences in iris behavior in the dark compared to light in PACS, PACD, and normal eyes add to the evidence that dynamic iris change has a role in the pathogenesis of PAC in a rural Chinese population.
Keyword Anterior segment optical coherence tomography
Iris cross-sectional area
Primary angle closure disease
Primary angle closure suspect
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
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