Prior knowledge of the clinical picture does not introduce bias in the histopathologic diagnosis of melanocytic skin lesions

Ferrara, Gerardo, Annessi, Giorgio, Argenyi, Zsolt, Argenziano, Giuseppe, Beltraminelli, Helmut, Cerio, Rino, Cerroni, Lorenzo, Cota, Carlo, Simonetti, Stefano, Stefanato, Catherine M., Zalaudek, Iris, Kittler, Harald and Soyer, H. Peter (2015) Prior knowledge of the clinical picture does not introduce bias in the histopathologic diagnosis of melanocytic skin lesions. Journal of Cutaneous Pathology, 42 12: 953-958. doi:10.1111/cup.12589


Author Ferrara, Gerardo
Annessi, Giorgio
Argenyi, Zsolt
Argenziano, Giuseppe
Beltraminelli, Helmut
Cerio, Rino
Cerroni, Lorenzo
Cota, Carlo
Simonetti, Stefano
Stefanato, Catherine M.
Zalaudek, Iris
Kittler, Harald
Soyer, H. Peter
Title Prior knowledge of the clinical picture does not introduce bias in the histopathologic diagnosis of melanocytic skin lesions
Journal name Journal of Cutaneous Pathology   Check publisher's open access policy
ISSN 1600-0560
0303-6987
Publication date 2015-12-01
Sub-type Article (original research)
DOI 10.1111/cup.12589
Open Access Status Not Open Access
Volume 42
Issue 12
Start page 953
End page 958
Total pages 6
Place of publication Hoboken, NJ, United States
Publisher Wiley-Blackwell Publishing
Collection year 2016
Language eng
Formatted abstract
A common debate among dermatopathologists is that prior knowledge of the clinical picture of melanocytic skin neoplasms may introduce a potential bias in the histopathologic examination. Histologic slides from 99 melanocytic skin neoplasms were circulated among 10 clinical dermatologists, all of them formally trained and board-certified dermatopathologists: 5 dermatopathologists had clinical images available after a ‘blind’ examination (Group 1); the other 5 had clinical images available before microscopic examination (Group 2). Data from the two groups were compared regarding ‘consensus’ (a diagnosis in agreement by ≥4 dermatopathologists/group), chance-corrected interobserver agreement (Fleiss' k) and level of diagnostic confidence (LDC: a 1–5 arbitrary scale indicating ‘increasing reliability’ of any given diagnosis). Compared with Group 1 dermatopathologists, Group 2 achieved a lower number of consensus (84 vs. 90) but a higher k value (0.74 vs. 0.69) and a greater mean LDC value (4.57 vs. 4.32). The same consensus was achieved by the two groups in 81/99 cases. Spitzoid neoplasms were most frequently controversial for both groups. The histopathologic interpretation of melanocytic neoplasms seems to be not biased by the knowledge of the clinical picture before histopathologic examination.
Keyword Clinical information
Clinicopathologic correlation
Dermoscopy
Histopathologic diagnosis
Melanocytic skin neoplasms
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2016 Collection
School of Medicine Publications
 
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