Regulation of rat brain angiotensin II (AII) receptors by intravenous AII and low dietary Na+

Thomas, WG and Sernia, C (1985) Regulation of rat brain angiotensin II (AII) receptors by intravenous AII and low dietary Na+. Brain Research, 345 1: 54-61. doi:10.1016/0006-8993(85)90835-2

Author Thomas, WG
Sernia, C
Title Regulation of rat brain angiotensin II (AII) receptors by intravenous AII and low dietary Na+
Journal name Brain Research   Check publisher's open access policy
ISSN 0006-8993
Publication date 1985-10-14
Year available 1985
Sub-type Article (original research)
DOI 10.1016/0006-8993(85)90835-2
Open Access Status Not Open Access
Volume 345
Issue 1
Start page 54
End page 61
Total pages 8
Language eng
Subject 1309 Developmental Biology
1312 Molecular Biology
2728 Clinical Neurology
2800 Neuroscience
Abstract Previous studies have shown the presence of specific AII receptors at several areas of the brain. The purpose of this study was to examine by radioreceptor assay the effect of intravenous AII infusion (5 or 25 ng/kg/min) and low dietary Na+ (<8 mmol/100 g) on AII receptors in five brain regions: the olfactory lobes (OLF), hypothalamus/thalamus/septum (HTS), midbrain (MID), cerebellum (CER) and medulla (MED). Scatchard analysis of binding data from control rats showed significant (P < 0.01 ANOVA) differences between brain areas in both Ka (1.54 OLF, 1.87 HTS, 1.25 MID, 1.33 MED, 0.77 CER × 109 M-1) and R0 (321 OLF, 224 HTS, 203 MID, 145 MED, 41 CER fmol/g tissue). Following the i.v. infusion of AII for 4-7 days, marked changes were observed in the areas with a porous BBB, the HTS and MED. Both the Ka [3.20 (HTS) and 0.67 (MED) × 109 M-1] and R0 [116 (HTS) and 249 (MED) fmol/g tissue] changed. In addition, decreases in R0 were also observed in the OLF (241 fmol/g tissue) and CER (21 fmol/g tissue), areas which have not been considered as being accessible to blood-borne AII. A low Na+ diet for 21-30 days changed the Ka and R0 in all five regions but not in similar directions. Furthermore, with the exception of the OLF the direction of change was not similar to that caused by i.v. infusion of AII. It was concluded that AII receptor sites in the rat brain differ from each other in both receptor properties and in their response to such regulatory factors as AII and Na+ depletion. In addition, the division of receptor sites into those within and those outside the BBB appears to lack functional significance since both types were affected by i.v. exogenous AII.
Keyword angiotensin receptor
receptor regulation
renin-angiotensin system
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
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