23Na NMR detects protection by glycine and alanine against hypoxic injury in the isolated perfused rat kidney

Endre, ZH, Cowin, GJ, Stewartrichardson, P, Cross, M, Willgoss, DA and Duggleby, RG (1994) 23Na NMR detects protection by glycine and alanine against hypoxic injury in the isolated perfused rat kidney. Biochemical and Biophysical Research Communications, 202 3: 1639-1644. doi:10.1006/bbrc.1994.2121


Author Endre, ZH
Cowin, GJ
Stewartrichardson, P
Cross, M
Willgoss, DA
Duggleby, RG
Title 23Na NMR detects protection by glycine and alanine against hypoxic injury in the isolated perfused rat kidney
Journal name Biochemical and Biophysical Research Communications   Check publisher's open access policy
ISSN 0006-291X
Publication date 1994-01-01
Year available 1994
Sub-type Article (original research)
DOI 10.1006/bbrc.1994.2121
Open Access Status Not yet assessed
Volume 202
Issue 3
Start page 1639
End page 1644
Total pages 6
Place of publication SAN DIEGO
Publisher ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS
Language eng
Subject 1303 Specialist Studies in Education
1304 Biophysics
1312 Molecular Biology
Abstract Protection against hypoxic injury by supraphysiological glycine and alanine concentrations was investigated in the isolated perfused rat kidney (IPRK). Na-23 NMR detects consistent increases in total renal Na in IPRK during hypoxic perfusion. Increasing the concentration of glycine and alanine to 5 mM each produced a 34% (p<0.001) reduction in the increase in total renal Na following 30 minutes of hypoxia compared to a matched control group supplemented with 5 mM each of serine and glutamine. There was also a trend (p=0.067) to improvement in the fractional excretion of sodium (FE(Na)) in the glycine plus alanine treated group. Hypoxic alterations of other physiological parameters were not prevented by supraphysiological glycine plus alanine. This suggests that monitoring total renal Na is a more sensitive method of defining renal injury and protection than monitoring changes in FE(Na), fractional excretion of potassium (FE(K)) and inulin clearance. (C) 1994 Academic Press, Inc.
Keyword Biochemistry & Molecular Biology
Biophysics
Biochemistry & Molecular Biology
Biophysics
BIOCHEMISTRY & MOLECULAR BIOLOGY
BIOPHYSICS
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import - Archived
 
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