Movement evoked pain and mechanical hyperalgesia after intramuscular injection of Nerve Growth Factor: A model of sustained elbow pain

Bergin, Michael Joseph Gerard, Hirata, Rogerio, Mista, Christian, Christensen, Steffan Wittrup, Tucker, Kylie, Vicenzino, Bill, Hodges, Paul and Graven-Nielsen, Thomas (2015) Movement evoked pain and mechanical hyperalgesia after intramuscular injection of Nerve Growth Factor: A model of sustained elbow pain. Pain Medicine, 16 11: 2180-2191. doi:10.1111/pme.12824


Author Bergin, Michael Joseph Gerard
Hirata, Rogerio
Mista, Christian
Christensen, Steffan Wittrup
Tucker, Kylie
Vicenzino, Bill
Hodges, Paul
Graven-Nielsen, Thomas
Title Movement evoked pain and mechanical hyperalgesia after intramuscular injection of Nerve Growth Factor: A model of sustained elbow pain
Journal name Pain Medicine   Check publisher's open access policy
ISSN 1526-2375
1526-4637
Publication date 2015-11-01
Sub-type Article (original research)
DOI 10.1111/pme.12824
Open Access Status Not Open Access
Volume 16
Issue 11
Start page 2180
End page 2191
Total pages 12
Place of publication Cary, NC, United States
Publisher Oxford University Press
Language eng
Formatted abstract
Objective: Lateral epicondylalgia presents as lateral elbow pain provoked by upper limb tasks. An experimental model of elbow pain provoked by movement/muscle contraction and maintained over several days is required to better understand the mechanisms underlying sustained elbow pain. This study investigated the time course and pain location induced by nerve growth factor (NGF) injection into a wrist extensor muscle, and whether movement and muscle contraction/stretch provoked pain.

Methods: On Day 0 twenty-six painfree volunteers were injected with NGF (N=13) or isotonic saline (randomized) into the extensor carpi radialis brevis (ECRB) muscle of the dominant arm. On Day 2 pain was induced in all participants by hypertonic saline injection into ECRB. A Likert scale and patient-rated tennis elbow evaluation (PRTEE) was used to assess pain and functional limitation (Days 0-10). Pain intensity during contraction/stretch of ECRB, and pressure pain thresholds (PPTs) were recorded before and after injections on Days 0 and 2, and Days 4 and 10.

Results: Compared with isotonic saline, NGF evoked: i) greater Likert pain ratings from 12 hours post-injection until Day 6, ii) greater PRTEE scores on Days 2 and 4, iii) greater pain during ECRB contraction/stretch on Day 2, and iv) lower PPTs on Day 4.

Conclusions: This article presents a novel experimental human pain model suitable to study the sustained effects of lateral elbow pain on sensorimotor function and to probe the mechanisms underlying persistent musculoskeletal pain.
Keyword Elbow pain
Hyperalgesia
Muscle contraction
Muscle stretch
Nerve growth factor
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2016 Collection
School of Health and Rehabilitation Sciences Publications
 
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Created: Thu, 04 Feb 2016, 23:06:14 EST by Ms Kylie Tucker on behalf of School of Health & Rehabilitation Sciences