Advances in the diagnosis of human schistosomiasis

Weerakoon, Kosala G. A. D., Gobert, Geoffrey N., Cai, Pengfei and McManus, Donald P. (2015) Advances in the diagnosis of human schistosomiasis. Clinical Microbiology Reviews, 28 4: 939-967. doi:10.1128/CMR.00137-14

Author Weerakoon, Kosala G. A. D.
Gobert, Geoffrey N.
Cai, Pengfei
McManus, Donald P.
Title Advances in the diagnosis of human schistosomiasis
Journal name Clinical Microbiology Reviews   Check publisher's open access policy
ISSN 1098-6618
Publication date 2015-10-01
Sub-type Article (original research)
DOI 10.1128/CMR.00137-14
Open Access Status DOI
Volume 28
Issue 4
Start page 939
End page 967
Total pages 29
Place of publication Washington, DC, United States
Publisher American Society for Microbiology
Language eng
Abstract Schistosomiasis is a major neglected tropical disease that afflicts more than 240 million people, including many children and young adults, in the tropics and subtropics. The disease is characterized by chronic infections with significant residual morbidity and is of considerable public health importance, with substantial socioeconomic impacts on impoverished communities. Morbidity reduction and eventual elimination through integrated intervention measures are the focuses of current schistosomiasis control programs. Precise diagnosis of schistosome infections, in both mammalian and snail intermediate hosts, will play a pivotal role in achieving these goals. Nevertheless, despite extensive efforts over several decades, the search for sensitive and specific diagnostics for schistosomiasis is ongoing. Here we review the area, paying attention to earlier approaches but emphasizing recent developments in the search for new diagnostics for schistosomiasis with practical applications in the research laboratory, the clinic, and the field. Careful and rigorous validation of these assays and their cost-effectiveness will be needed, however, prior to their adoption in support of policy decisions for national public health programs aimed at the control and elimination of schistosomiasis.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2016 Collection
School of Public Health Publications
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