Variability in management of early severe sepsis

Reade, Michael C., Huang, David T., Bell, Derek, Coats, Timothy J., Cross, Anthony M., Moran, John L., Peake, Sandra L., Singer, Mervyn, Yealy, Donald M. and Angus, Derek C. (2010) Variability in management of early severe sepsis. Emergency Medicine Journal, 27 2: 110-115. doi:10.1136/emj.2008.070912

Author Reade, Michael C.
Huang, David T.
Bell, Derek
Coats, Timothy J.
Cross, Anthony M.
Moran, John L.
Peake, Sandra L.
Singer, Mervyn
Yealy, Donald M.
Angus, Derek C.
Title Variability in management of early severe sepsis
Journal name Emergency Medicine Journal   Check publisher's open access policy
ISSN 1472-0205
Publication date 2010-02-01
Year available 2010
Sub-type Article (original research)
DOI 10.1136/emj.2008.070912
Open Access Status Not yet assessed
Volume 27
Issue 2
Start page 110
End page 115
Total pages 6
Place of publication London, United Kingdom
Publisher B M J Group
Language eng
Formatted abstract
Objective: A study was undertaken to characterise how doctors in emergency medicine (EM), acute medicine (AM) and critical care (ICU) in the UK, USA and Australia and New Zealand (ANZ) approach the initial resuscitative care of patients with severe sepsis.

Methods: In 2007, members on the mailing lists of UK, US and ANZ EM, ICU and AM specialist organisations were invited to answer an anonymous scenario-based online survey. Respondents described their management of a patient with pneumonia and signs of sepsis. Multiple-choice questions were based on the Surviving Sepsis Campaign (SSC) 6-hour resuscitation bundle guidelines while avoiding the specific terms "sepsis" and "SSC guidelines".

Results: The response rate was 21% (2461/11 795). Only two respondents (0.1%) complied with all SSC resuscitation recommendations. Inter-specialty and intercountry variations included differences in reporting initial lactate measurement (ranging from 30% in US-EM to 79% in UK-EM), fluid resuscitation targeting a central venous pressure of 8 - 12 mm Hg (from 15% in ANZ-ICU to 60% in UK-EM), blood transfusion for a central venous oxygen saturation <70% and haematocrit <30% (from 15% in ANZ-ICU to 70% in US-EM and UK-EM) and insertion of invasive monitoring (intra-arterial catheter: 89% in UK-ICU vs 20% in US-EM; central venous catheter: 83% in UK-ICU vs 44% in US-EM). 81% of respondents identified at least one reason why they did not implement all the recommendations; the reasons varied by region and specialty.

Conclusions: Reported management of early sepsis varies between specialities and countries, and the responses do not follow SSC guidelines. Concerns relate to knowledge, attitudes and resources.
Keyword Emergency Medicine
Emergency Medicine
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID GM076659
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 49 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 58 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Tue, 02 Feb 2016, 22:18:29 EST by System User on behalf of Learning and Research Services (UQ Library)