A regulatory gene network related to the porcine umami taste receptor (TAS1R1/TAS1R3)

Kim, J. M., Ren, D., Reverter, A. and Roura, E. (2016) A regulatory gene network related to the porcine umami taste receptor (TAS1R1/TAS1R3). Animal Genetics, 47 1: 114-119. doi:10.1111/age.12374


Author Kim, J. M.
Ren, D.
Reverter, A.
Roura, E.
Title A regulatory gene network related to the porcine umami taste receptor (TAS1R1/TAS1R3)
Formatted title
A regulatory gene network related to the porcine umami taste receptor (TAS1R1/TAS1R3)
Journal name Animal Genetics   Check publisher's open access policy
ISSN 1365-2052
0268-9146
Publication date 2016-02-01
Year available 2015
Sub-type Article (original research)
DOI 10.1111/age.12374
Open Access Status Not Open Access
Volume 47
Issue 1
Start page 114
End page 119
Total pages 6
Place of publication Chichester, West Sussex, United Kingdom
Publisher Wiley-Blackwell Publishing
Language eng
Subject 1103 Animal Science and Zoology
1311 Genetics
Abstract Taste perception plays an important role in the mediation of food choices in mammals. The first porcine taste receptor genes identified, sequenced and characterized, TAS1R1 and TAS1R3, were related to the dimeric receptor for umami taste. However, little is known about their regulatory network. The objective of this study was to unfold the genetic network involved in porcine umami taste perception. We performed a meta-analysis of 20 gene expression studies spanning 480 porcine microarray chips and screened 328 taste-related genes by selective mining steps among the available 12 320 genes. A porcine umami taste-specific regulatory network was constructed based on the normalized coexpression data of the 328 genes across 27 tissues. From the network, we revealed the 'taste module' and identified a coexpression cluster for the umami taste according to the first connector with the TAS1R1/TAS1R3 genes. Our findings identify several taste-related regulatory genes and extend previous genetic background of porcine umami taste.
Formatted abstract
Taste perception plays an important role in the mediation of food choices in mammals. The first porcine taste receptor genes identified, sequenced and characterized, TAS1R1 and TAS1R3, were related to the dimeric receptor for umami taste. However, little is known about their regulatory network. The objective of this study was to unfold the genetic network involved in porcine umami taste perception. We performed a meta-analysis of 20 gene expression studies spanning 480 porcine microarray chips and screened 328 taste-related genes by selective mining steps among the available 12 320 genes. A porcine umami taste-specific regulatory network was constructed based on the normalized coexpression data of the 328 genes across 27 tissues. From the network, we revealed the ‘taste module’ and identified a coexpression cluster for the umami taste according to the first connector with the TAS1R1/TAS1R3 genes. Our findings identify several taste-related regulatory genes and extend previous genetic background of porcine umami taste.
Keyword Gene microarray
Regulatory network
T1R
Taste receptors
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ
Additional Notes Published online 11 November 2015

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Alliance for Agriculture and Food Innovation
Official 2016 Collection
 
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