Epidermal growth factor receptor transactivation: mechanisms, pathophysiology, and potential therapies in the cardiovascular system

Forrester, Steven J., Kawai, Tatsuo, O'Brien, Shannon, Thomas, Walter, Harris, Raymond C. and Eguchi, Satoru (2016) Epidermal growth factor receptor transactivation: mechanisms, pathophysiology, and potential therapies in the cardiovascular system. Annual Review of Pharmacology and Toxicology, 56 627-653. doi:10.1146/annurev-pharmtox-070115-095427


Author Forrester, Steven J.
Kawai, Tatsuo
O'Brien, Shannon
Thomas, Walter
Harris, Raymond C.
Eguchi, Satoru
Title Epidermal growth factor receptor transactivation: mechanisms, pathophysiology, and potential therapies in the cardiovascular system
Journal name Annual Review of Pharmacology and Toxicology   Check publisher's open access policy
ISSN 1545-4304
0362-1642
Publication date 2016-01-06
Sub-type Article (original research)
DOI 10.1146/annurev-pharmtox-070115-095427
Open Access Status Not Open Access
Volume 56
Start page 627
End page 653
Total pages 27
Place of publication Palo Alto, CA, United States
Publisher Annual Reviews
Language eng
Abstract Epidermal growth factor receptor (EGFR) activation impacts the physiology and pathophysiology of the cardiovascular system, and inhibition of EGFR activity is emerging as a potential therapeutic strategy to treat diseases including hypertension, cardiac hypertrophy, renal fibrosis, and abdominal aortic aneurysm. The capacity of G protein-coupled receptor (GPCR) agonists, such as angiotensin II (AngII), to promote EGFR signaling is called transactivation and is well described, yet delineating the molecular processes and functional relevance of this crosstalk has been challenging. Moreover, these critical findings are dispersed among many different fields. The aim of our review is to highlight recent advancements in defining the signaling cascades and downstream consequences of EGFR transactivation in the cardiovascular renal system. We also focus on studies that link EGFR transactivation to animal models of the disease, and we discuss potential therapeutic applications.
Keyword Aldosterone
Angiotensin II
Endothelium
Heart
Kidney
Signal transduction
Vascular smooth muscle
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
School of Biomedical Sciences Publications
 
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