Understanding the human pedunculopontine nucleus in Parkinson’s disease

Fytagoridis, Anders, Silburn, Peter A., Coyne, Terry J. and Thevathasan, Wesley (2016) Understanding the human pedunculopontine nucleus in Parkinson’s disease. Journal of Neural Transmission, 123 7: 769-774. doi:10.1007/s00702-016-1505-x

Author Fytagoridis, Anders
Silburn, Peter A.
Coyne, Terry J.
Thevathasan, Wesley
Title Understanding the human pedunculopontine nucleus in Parkinson’s disease
Journal name Journal of Neural Transmission   Check publisher's open access policy
ISSN 1435-1463
Publication date 2016-07-01
Year available 2016
Sub-type Article (original research)
DOI 10.1007/s00702-016-1505-x
Open Access Status Not Open Access
Volume 123
Issue 7
Start page 769
End page 774
Total pages 6
Place of publication Wien, Austria
Publisher Springer Wien
Language eng
Subject 2808 Neurology
2728 Clinical Neurology
2738 Psychiatry and Mental health
2803 Biological Psychiatry
Abstract This paper presents the Brisbane experience of pedunculopontine nucleus (PPN) deep brain stimulation (DBS) in Parkinson’s disease (PD). Clinical outcomes along with studies of the mechanisms and neurophysiology of PPN in PD patients with severe freezing of gait (FoG) and postural imbalance (PI) are summarised and presented. Our results indicate that PPN DBS improves FoG and falls in the relatively uncommon group of PD patients who respond well to medication other than for continuing on time FoG and falls. Our studies indicate that bilateral DBS is more beneficial than unilateral DBS, and that the more caudal region of the PPN seems preferable for stimulation. There is evidence that rapid-release programs for initiation and correction of gait and posture are modulated by the PPN, possibly to some extent independently of the cerebral cortex. These functions were found to be impaired in PD patients with severe FoG/PI, but to some extent corrected by bilateral PPN DBS.
Keyword Deep brain stimulation
Freezing of gait
Pedunculopontine nucleus
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
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Queensland Brain Institute Publications
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