Invasive group A Streptococcus infection among children, rural Kenya

Seale, Anna C., Davies, Mark R., Anampiu, Kirimi, Morpeth, Susan C., Nyongesa, Sammy, Mwarumba, Salim, Smeesters, Pierre R., Efstratiou, Androulla, Karugutu, Rosylene, Mturi, Neema, Williams, Thomas N., Scott, J. Anthony G., Kariuki, Samuel, Dougan, Gordon and Berkley, James A. (2016) Invasive group A Streptococcus infection among children, rural Kenya. Emerging Infectious Diseases, 22 2: 224-232. doi:10.3201/eid2202.151358

Author Seale, Anna C.
Davies, Mark R.
Anampiu, Kirimi
Morpeth, Susan C.
Nyongesa, Sammy
Mwarumba, Salim
Smeesters, Pierre R.
Efstratiou, Androulla
Karugutu, Rosylene
Mturi, Neema
Williams, Thomas N.
Scott, J. Anthony G.
Kariuki, Samuel
Dougan, Gordon
Berkley, James A.
Title Invasive group A Streptococcus infection among children, rural Kenya
Formatted title
Invasive group A Streptococcus infection among children, rural Kenya
Journal name Emerging Infectious Diseases   Check publisher's open access policy
ISSN 1080-6059
Publication date 2016-02-01
Year available 2016
Sub-type Article (original research)
DOI 10.3201/eid2202.151358
Open Access Status DOI
Volume 22
Issue 2
Start page 224
End page 232
Total pages 9
Place of publication Atlanta, GA, United States
Publisher U.S. Department of Health and Human Services * Centers for Disease Control and Prevention
Language eng
Formatted abstract
To determine the extent of group A Streptococcus (GAS) infections in sub-Saharan Africa and the serotypes that cause disease, we analyzed surveillance data for 64,741 hospital admissions in Kilifi, Kenya, during 1998-2011. We evaluated incidence, clinical presentations, and emm types that cause invasive GAS infection. We detected 370 cases; of the 369 for which we had data, most were skin and soft tissue infections (70%), severe pneumonia (23%), and primary bacteremia (14%). Overall case-fatality risk was 12%. Incidence of invasive GAS infection was 0.6 cases/1,000 live births among neonates, 101/100,000 person-years among children <1 year of age, and 35/100,000 among children <5 years of age. Genome sequencing identified 88 emm types. GAS causes serious disease in children in rural Kenya, especially neonates, and the causative organ- isms have considerable genotypic diversity. Benefit from the most advanced GAS type-specific vaccines may be limited, and efforts must be directed to protect against disease in regions of high incidence.
Keyword Group A Streptococcus infection
Rural Kenya
Skin and soft tissue infections
Necrotizing fasciitis
Emm types
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
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