Spatial memory training induces morphological changes detected by manganese-enhanced MRI in the hippocampal CA3 mossy fiber terminal zone

Zhang, Binbin, Chuang, Kai-Hsiang, Tjio, Ci'en, Chen, Way Cherng, Sheu, Fwu-Shan and Routtenberg, Aryeh (2016) Spatial memory training induces morphological changes detected by manganese-enhanced MRI in the hippocampal CA3 mossy fiber terminal zone. NeuroImage, 128 227-237. doi:10.1016/j.neuroimage.2015.07.084


Author Zhang, Binbin
Chuang, Kai-Hsiang
Tjio, Ci'en
Chen, Way Cherng
Sheu, Fwu-Shan
Routtenberg, Aryeh
Title Spatial memory training induces morphological changes detected by manganese-enhanced MRI in the hippocampal CA3 mossy fiber terminal zone
Journal name NeuroImage   Check publisher's open access policy
ISSN 1095-9572
1053-8119
Publication date 2016-03-01
Year available 2016
Sub-type Article (original research)
DOI 10.1016/j.neuroimage.2015.07.084
Open Access Status Not Open Access
Volume 128
Start page 227
End page 237
Total pages 11
Place of publication Amsterdam, Netherlands
Publisher Elsevier
Language eng
Abstract Hippocampal mossy fibers (MFs) can show plasticity of their axon terminal arbor consequent to learning a spatial memory task. Such plasticity is seen as translaminar sprouting from the stratum lucidum (SL) of CA3 into the stratum pyramidale (SP) and the stratum oriens (SO). However, the functional role of this presynaptic remodeling is still obscure. In vivo imaging that allows longitudinal observation of such remodeling could provide a deeper understanding of this presynaptic growth phenomenon as it occurs over time. Here we used manganese-enhanced magnetic resonance imaging (MEMRI), which shows a high-contrast area that co-localizes with the MFs. This technique was applied in the detection of learning-induced MF plasticity in two strains of rats. Quantitative analysis of a series of sections in the rostral dorsal hippocampus showed increases in the CA3a′ area in MEMRI of trained Wistar rats consistent with the increased SO + SP area seen in the Timm's staining. MF plasticity was not seen in the trained Lister-Hooded rats in either MEMRI or in Timm's staining. This indicates the potential of MEMRI for revealing neuro-architectures and plasticity of the hippocampal MF system in vivo in longitudinal studies.
Keyword Hippocampal mossy fibers
Presynaptic plasticity
MRI
Spatial learning
Memory
Water maze
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
Queensland Brain Institute Publications
Centre for Advanced Imaging Publications
 
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