The relationship between opioid use and overactivity in chronic pain: a five day observational study

Andrews, Nicole Emma, Strong, Jenny, Meredith, Pamela Joy and Fleming, Julia Ann (2016) The relationship between opioid use and overactivity in chronic pain: a five day observational study. Pain, 157 2: 466-474. doi:10.1097/j.pain.0000000000000384

Author Andrews, Nicole Emma
Strong, Jenny
Meredith, Pamela Joy
Fleming, Julia Ann
Title The relationship between opioid use and overactivity in chronic pain: a five day observational study
Journal name Pain   Check publisher's open access policy
ISSN 0304-3959
Publication date 2016-01-01
Year available 2016
Sub-type Article (original research)
DOI 10.1097/j.pain.0000000000000384
Open Access Status Not Open Access
Volume 157
Issue 2
Start page 466
End page 474
Total pages 9
Place of publication Philadelphia, PA, United States
Publisher Lippincott Williams & Wilkins
Language eng
Abstract With increasing concerns about the potential harm of long-term opioid therapy, there is a need for the development and implementation of alternative treatment strategies for patients with chronic pain who have been using opioids for a prolonged period of time. Based on the findings from a recent qualitative investigation that suggested there may be a bidirectional association between opioid reliance and habitual overactivity behaviour (activity engagement that significantly exacerbates pain), this study was designed to quantitatively investigate the association between opioid use and habitual overactivity over a 5-day period in a group of chronic pain patients. Participants provided a list of their prescribed pain medication, completed a self-report measure of habitual overactivity, and then commenced 5 days of data collection. Data collection required participants to wear an activity monitor and to complete a diary that detailed their daily activities and the time at which they took medication. Individuals reporting higher levels of habitual overactivity were more likely to be prescribed opioids. In addition, higher levels of habitual overactivity were associated with more frequent pro re nata (“as needed”) opioid use over the 5 days, and with a discrepancy between the prescribed and actual oral morphine-equivalent daily dose, where more medication was taken than was prescribed. There was no predominant context for pro re nata use. The results of this study support the idea that habitual overactivity behaviour may play a role in the development of reliance on opioid medication and that such an association may provide a potential treatment target for opioid therapy rationalisation.
Keyword Chronic pain
Activity avoidance
Opioid therapy
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: School of Health and Rehabilitation Sciences Publications
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Created: Tue, 02 Feb 2016, 01:56:24 EST by Dr Pamela Meredith on behalf of School of Health & Rehabilitation Sciences