Phyllodes tumours of the breast: A consensus review

Tan, Benjamin Y., Acs, Geza, Apple, Sophia K., Badve, Sunil, Bleiweiss, Ira J., Brogi, Edi, Calvo, Jose P., Dabbs, David J., Ellis, Ian O., Eusebi, Vincenzo, Farshid, Gelareh, Fox, Stephen B., Ichihara, Shu, Lakhani, Sunil R., Rakha, Emad A., Reis-Filho, Jorge S., Richardson, Andrea L., Sahin, Aysegul, Schmitt, Fernando C., Schnitt, Stuart J., Siziopikou, Kalliopi P., Soares, Fernando A., Tse, Gary M., Vincent-Salomon, Anne and Puay Hoon Tan (2016) Phyllodes tumours of the breast: A consensus review. Histopathology, 68 1: 5-21. doi:10.1111/his.12876

Author Tan, Benjamin Y.
Acs, Geza
Apple, Sophia K.
Badve, Sunil
Bleiweiss, Ira J.
Brogi, Edi
Calvo, Jose P.
Dabbs, David J.
Ellis, Ian O.
Eusebi, Vincenzo
Farshid, Gelareh
Fox, Stephen B.
Ichihara, Shu
Lakhani, Sunil R.
Rakha, Emad A.
Reis-Filho, Jorge S.
Richardson, Andrea L.
Sahin, Aysegul
Schmitt, Fernando C.
Schnitt, Stuart J.
Siziopikou, Kalliopi P.
Soares, Fernando A.
Tse, Gary M.
Vincent-Salomon, Anne
Puay Hoon Tan
Title Phyllodes tumours of the breast: A consensus review
Journal name Histopathology   Check publisher's open access policy
ISSN 1365-2559
Publication date 2016-01-01
Year available 2015
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1111/his.12876
Open Access Status Not yet assessed
Volume 68
Issue 1
Start page 5
End page 21
Total pages 17
Place of publication West Sussex, United Kingdom
Publisher Blackwell Publishing Ltd
Language eng
Subject 2722 Histology
2734 Pathology and Forensic Medicine
Abstract Phyllodes tumours constitute an uncommon but complex group of mammary fibroepithelial lesions. Accurate and reproducible grading of these tumours has long been challenging, owing to the need to assess multiple stratified histological parameters, which may be weighted differently by individual pathologists. Distinction of benign phyllodes tumours from cellular fibroadenomas is fraught with difficulty, due to overlapping microscopic features. Similarly, separation of the malignant phyllodes tumour from spindle cell metaplastic carcinoma and primary breast sarcoma can be problematic. Phyllodes tumours are treated by surgical excision. However, there is no consensus on the definition of an appropriate surgical margin to ensure completeness of excision and reduction of recurrence risk. Interpretive subjectivity, overlapping histological diagnostic criteria, suboptimal correlation between histological classification and clinical behaviour and the lack of robust molecular predictors of outcome make further investigation of the pathogenesis of these fascinating tumours a matter of active research. This review consolidates the current understanding of their pathobiology and clinical behaviour, and includes proposals for a rational approach to the classification and management of phyllodes tumours.
Keyword Classification
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ
Additional Notes Article first published online: 4 DEC 2015

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: UQ Centre for Clinical Research Publications
Official 2016 Collection
School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 37 times in Thomson Reuters Web of Science Article | Citations
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