Spatial cognition in adult and aged mice exposed to high-fat diet

Kesby, James P., Kim, Jane J., Scadeng, Miriam, Woods, Gina, Kado, Deborah M., Olefsky, Jerrold M., Jeste, Dilip V., Achim, Cristian L. and Semenova, Svetlana (2015) Spatial cognition in adult and aged mice exposed to high-fat diet. PLoS ONE, 10 10: 0140034.1-0140034.15. doi:10.1371/journal.pone.0140034


Author Kesby, James P.
Kim, Jane J.
Scadeng, Miriam
Woods, Gina
Kado, Deborah M.
Olefsky, Jerrold M.
Jeste, Dilip V.
Achim, Cristian L.
Semenova, Svetlana
Title Spatial cognition in adult and aged mice exposed to high-fat diet
Journal name PLoS ONE   Check publisher's open access policy
ISSN 1932-6203
Publication date 2015-10-08
Sub-type Article (original research)
DOI 10.1371/journal.pone.0140034
Open Access Status DOI
Volume 10
Issue 10
Start page 0140034.1
End page 0140034.15
Total pages 15
Place of publication San Francisco, United States
Publisher Public Library of Science
Language eng
Formatted abstract
Aging is associated with a decline in multiple aspects of cognitive function, with spatial cognition being particularly sensitive to age-related decline. Environmental stressors, such as high-fat diet (HFD) exposure, that produce a diabetic phenotype and metabolic dysfunction may indirectly lead to exacerbated brain aging and promote the development of cognitive deficits. The present work investigated whether exposure to HFD exacerbates age-related cognitive deficits in adult versus aged mice. Adult (5 months old) and aged (15 months old) mice were exposed to control diet or HFD for three months prior to, and throughout, behavioral testing. Anxiety-like behavior in the light-dark box test, discrimination learning and memory in the novel object/place recognition tests, and spatial learning and memory in the Barnes maze test were assessed. HFD resulted in significant gains in body weight and fat mass content with adult mice gaining significantly more weight and adipose tissue due to HFD than aged mice. Weight gain was attributed to food calories sourced from fat, but not total calorie intake. HFD increased fasting insulin levels in all mice, but adult mice showed a greater increase relative to aged mice. Behaviorally, HFD increased anxiety-like behavior in adult but not aged mice without significantly affecting spatial cognition. In contrast, aged mice fed either control or HFD diet displayed deficits in novel place discrimination and spatial learning. Our results suggest that adult mice are more susceptible to the physiological and anxiety-like effects of HFD consumption than aged mice, while aged mice displayed deficits in spatial cognition regardless of dietary influence. We conclude that although HFD induces systemic metabolic dysfunction in both adult and aged mice, overall cognitive function was not adversely affected under the current experimental conditions.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Non HERDC
Queensland Brain Institute Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 11 times in Thomson Reuters Web of Science Article | Citations
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