Autonomic activity during human sleep as a function of time and sleep stage

Trinder, J, Kleiman, J, Carrington, M, Smith, S, Breen, S, Tan, N and Kim, Y (2001) Autonomic activity during human sleep as a function of time and sleep stage. Journal of Sleep Research, 10 4: 253-264. doi:10.1046/j.1365-2869.2001.00263.x

Author Trinder, J
Kleiman, J
Carrington, M
Smith, S
Breen, S
Tan, N
Kim, Y
Title Autonomic activity during human sleep as a function of time and sleep stage
Journal name Journal of Sleep Research   Check publisher's open access policy
ISSN 0962-1105
Publication date 2001-01-01
Year available 2001
Sub-type Article (original research)
DOI 10.1046/j.1365-2869.2001.00263.x
Open Access Status Not yet assessed
Volume 10
Issue 4
Start page 253
End page 264
Total pages 12
Place of publication OXFORD
Language eng
Abstract While there is a developing understanding of the influence of sleep on cardiovascular autonomic activity in humans, there remain unresolved issues. In particular, the effect of time within the sleep period, independent of sleep stage, has not been investigated. Further, the influence of sleep on central sympathetic nervous system (SNS) activity is uncertain because results using the major method applicable to humans, the low frequency (LF) component of heart rate Variability (HRV), have been contradictory, and because the method itself is open to criticism. Sleep and cardiac activity were measured in 14 young healthy subjects on three nights. Data was analysed in 2-min epochs. All epochs meeting specified criteria were identified, beginning 2 h before, until 7 h after, sleep onset. Epoch values were allocated to 30-min bins and during sleep were also classified into stage 2, slow wave sleep (SWS) and rapid eye movement (REM) sleep. The measures of cardiac activity were heart irate (HR), blood pressure (BP), high frequency (HF) and LF components of HRV and pre-ejection period (PEP). During non-rapid eye movement (NREM) sleep autonomic balance shifted from sympathetic to parasympathetic dominance, although this appeared to be more because of a shift in parasympathetic nervous system (PNS) activity. Autonomic balance during REM was in general similar to wakefulness. For BP and the HF and LF components the change occurred abruptly at sleep onset and was then constant over time within each stage of sleep, indicating that any change in autonomic balance over the sleep period is a consequence of the changing distribution of sleep stages. Two variables, HR and PEP, did show time effects reflecting a circadian influence over HR and perhaps time asleep affecting PEP. While both the LF component and PEP showed changes consistent with reduced sympathetic tone during sleep, their pattern of change over time differed.
Keyword Behavioral Sciences
Blood Pressure
Heart Rate
Sympathetic Nervous System
Parasympathetic Nervous System
Sleep Onset
Vagal Tone
Sympathetic-nerve Activity
24-hour Blood-pressure
System Activity
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Psychology Publications
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Citation counts: TR Web of Science Citation Count  Cited 197 times in Thomson Reuters Web of Science Article | Citations
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Created: Mon, 13 Aug 2007, 22:42:52 EST