Macrophages: Their Emerging Roles in Bone

Sinder, Benjamin P., Pettit, Allison R. and McCauley, Laurie K. (2015) Macrophages: Their Emerging Roles in Bone. Journal of Bone and Mineral Research, 30 12: 2140-2149. doi:10.1002/jbmr.2735

Author Sinder, Benjamin P.
Pettit, Allison R.
McCauley, Laurie K.
Title Macrophages: Their Emerging Roles in Bone
Journal name Journal of Bone and Mineral Research   Check publisher's open access policy
ISSN 1523-4681
Publication date 2015-12-01
Year available 2015
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1002/jbmr.2735
Open Access Status Not yet assessed
Volume 30
Issue 12
Start page 2140
End page 2149
Total pages 10
Place of publication Hoboken, NJ, United States
Publisher Wiley-Blackwell Publishing
Language eng
Subject 2712 Endocrinology, Diabetes and Metabolism
2732 Orthopedics and Sports Medicine
Abstract Macrophages are present in nearly all tissues and are critical for development, homeostasis, and regeneration. Resident tissue macrophages of bone, termed osteal macrophages, are recently classified myeloid cells that are distinct from osteoclasts. Osteal macrophages are located immediately adjacent to osteoblasts, regulate bone formation, and play diverse roles in skeletal homeostasis. Genetic or pharmacological modulation of macrophages in vivo results in significant bone phenotypes, and these phenotypes depend on which macrophage subsets are altered. Macrophages are also key mediators of osseous wound healing and fracture repair, with distinct roles at various stages of the repair process. A central function of macrophages is their phagocytic ability. Each day, billions of cells die in the body and efferocytosis (phagocytosis of apoptotic cells) is a critical process in both clearing dead cells and recruitment of replacement progenitor cells to maintain homeostasis. Recent data suggest a role for efferocytosis in bone biology and these new mechanisms are outlined. Finally, although macrophages have an established role in primary tumors, emerging evidence suggests that macrophages in bone support cancers which preferentially metastasize to the skeleton. Collectively, this developing area of osteoimmunology raises new questions and promises to provide novel insights into pathophysiologic conditions as well as therapeutic and regenerative approaches vital for skeletal health.
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID DK053904
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Mater Research Institute-UQ (MRI-UQ)
Official 2016 Collection
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Citation counts: TR Web of Science Citation Count  Cited 23 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 27 times in Scopus Article | Citations
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