Recent advances in oral delivery of peptide hormones

Varamini, Pegah and Toth, Istvan (2016) Recent advances in oral delivery of peptide hormones. Expert Opinion on Drug Delivery, 13 4: 507-522. doi:10.1517/17425247.2016.1142526

Author Varamini, Pegah
Toth, Istvan
Title Recent advances in oral delivery of peptide hormones
Journal name Expert Opinion on Drug Delivery   Check publisher's open access policy
ISSN 1742-5247
Publication date 2016-01-01
Year available 2016
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1517/17425247.2016.1142526
Open Access Status Not Open Access
Volume 13
Issue 4
Start page 507
End page 522
Total pages 16
Place of publication Abingdon, Oxfordshire, United Kingdom
Publisher Taylor & Francis
Language eng
Formatted abstract
Introduction: Oral delivery of therapeutic peptide hormones offers the promise of greater patient compliance when compared to parenteral administration routes. However, it is a huge challenge in the pharmaceutical field. Due to increasing demand for oral delivery of peptide hormones such as insulin, gonadotropin-releasing hormones, and calcitonin, various technologies have been explored to overcome the associated hurdles.

Areas covered: This review article summarizes the physiological barriers to the oral delivery of peptide hormones and some of the key strategies to circumvent these barriers and enhance peptide hormones’ oral bioavailability. In addition, recent advances in oral formulation strategies of peptide hormones, under development and within the clinical trial stages, are discussed.

Expert Opinion: The pharmaceutical industry has devoted much effort to develop new, and often complex peptide hormone products based on formulation strategy. Use of the native structure of the peptide hormones in oral formulations could result in an unpredictable pharmacokinetic profile. Authors believe that considering chemical modification prior to formulation is essential to achieve orally active products.

Although no major breakthrough has been achieved for effective oral delivery of peptides hormones yet, the substantial efforts by industrial and academic laboratories might yield successful results in near future.
Keyword Chemical modification
Clinical trial
Metabolic stability
Oral bioavailability
Oral delivery
Peptide hormones
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: HERDC Pre-Audit
School of Chemistry and Molecular Biosciences
School of Pharmacy Publications
Institute for Molecular Bioscience - Publications
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Citation counts: TR Web of Science Citation Count  Cited 5 times in Thomson Reuters Web of Science Article | Citations
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Created: Fri, 22 Jan 2016, 19:45:18 EST by Mrs Louise Nimwegen on behalf of School of Chemistry & Molecular Biosciences