Advances in silica based nanoparticles for targeted cancer therapy

Yang, Yannan and Yu, Chengzhong (2015) Advances in silica based nanoparticles for targeted cancer therapy. Nanomedicine: Nanotechnology, Biology and Medicine, 12 2: 317-332. doi:10.1016/j.nano.2015.10.018

Author Yang, Yannan
Yu, Chengzhong
Title Advances in silica based nanoparticles for targeted cancer therapy
Journal name Nanomedicine: Nanotechnology, Biology and Medicine   Check publisher's open access policy
ISSN 1549-9634
Publication date 2015-01-01
Year available 2015
Sub-type Article (original research)
DOI 10.1016/j.nano.2015.10.018
Open Access Status Not Open Access
Volume 12
Issue 2
Start page 317
End page 332
Total pages 16
Place of publication Philadelphia, PA United States
Publisher Elsevier
Language eng
Subject 1502 Bioengineering
2701 Medicine (miscellaneous)
1313 Molecular Medicine
2204 Biomedical Engineering
2500 Materials Science
3003 Pharmaceutical Science
Abstract Targeted delivery of anticancer drug specifically to tumor site without damaging normal tissues has been the dream of all scientists fighting against cancer for decades. Recent breakthrough on nanotechnology based medicines has provided a possible tool to solve this puzzle. Among diverse nanomaterials that are under development and extensive study, silica based nanoparticles with vast advantages have attracted great attention. In this review, we concentrate on the recent progress using silica based nanoparticles, particularly mesoporous silica nanoparticles (MSNs), for targeted drug delivery applications. First, we discuss the passive targeting capability of silica based nanoparticles in relation to their physiochemical properties. Then, we focus on the recent advances of active targeting strategies involving tumor cell targeting, vascular targeting, nuclear targeting and multistage targeting, followed by an introduction to magnetic field directed targeting approach. We conclude with our personal perspectives on the remaining challenges and the possible future directions.
Keyword Silica nanoparticles
Active targeting
Passive targeting
Magnetic field directed targeting
Cancer therapy
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2016 Collection
Australian Institute for Bioengineering and Nanotechnology Publications
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Citation counts: TR Web of Science Citation Count  Cited 35 times in Thomson Reuters Web of Science Article | Citations
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Created: Thu, 21 Jan 2016, 02:06:59 EST by Chris Ende on behalf of Aust Institute for Bioengineering & Nanotechnology