Functional connectivity MRI tracks memory networks after maze learning in rodents

Nasrallah, Fatima A., To, Xuan Vinh, Chen, Der-Yow, Routtenberg, Aryeh and Chuang, Kai-Hsiang (2016) Functional connectivity MRI tracks memory networks after maze learning in rodents. NeuroImage, 127 196-202. doi:10.1016/j.neuroimage.2015.08.013

Author Nasrallah, Fatima A.
To, Xuan Vinh
Chen, Der-Yow
Routtenberg, Aryeh
Chuang, Kai-Hsiang
Title Functional connectivity MRI tracks memory networks after maze learning in rodents
Journal name NeuroImage   Check publisher's open access policy
ISSN 1095-9572
Publication date 2016-02-15
Year available 2015
Sub-type Article (original research)
DOI 10.1016/j.neuroimage.2015.08.013
Open Access Status Not Open Access
Volume 127
Start page 196
End page 202
Total pages 7
Place of publication Amsterdam, Netherlands
Publisher Elsevier
Language eng
Formatted abstract
Learning and memory employs a series of cognitive processes which require the coordination of multiple areas across the brain. However in vivo imaging of cognitive function has been challenging in rodents. Since these processes involve synchronous firing among different brain loci we explored functional connectivity imaging with resting-state fMRI. After 5-day training on a hidden platform watermaze task, notable signal correlations were seen between the hippocampal CA3 and other structures, including thalamus, septum and cingulate cortex, compared to swim control or naïve animals. The connectivity sustained 7 days after training and was reorganized toward the cortex, consistent with views of memory trace distribution leading to memory consolidation. These data demonstrates that, after a cognitive task, altered functional connectivity can be detected in the subsequently sedated rodent using in vivo imaging. This approach paves the way to understand dynamics of area-dependent distribution processes in animal models of cognition.
Keyword Functional connectivity
Learning and memory
Morris water maze
Neural plasticity
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ
Additional Notes Published online 20 August 2015

Document type: Journal Article
Sub-type: Article (original research)
Collections: Non HERDC
Queensland Brain Institute Publications
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Citation counts: TR Web of Science Citation Count  Cited 4 times in Thomson Reuters Web of Science Article | Citations
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