Astaxanthin has no effect on arterial stiffness, oxidative stress, or inflammation in renal transplant recipients: a randomized controlled trial (the XANTHIN trial)

Coombes, Jeff S., Sharman, James E. and Fassett, Robert G. (2016) Astaxanthin has no effect on arterial stiffness, oxidative stress, or inflammation in renal transplant recipients: a randomized controlled trial (the XANTHIN trial). The American Journal of Clinical Nutrition, 103 1: 283-289. doi:10.3945/​ajcn.115.115477

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Author Coombes, Jeff S.
Sharman, James E.
Fassett, Robert G.
Title Astaxanthin has no effect on arterial stiffness, oxidative stress, or inflammation in renal transplant recipients: a randomized controlled trial (the XANTHIN trial)
Journal name The American Journal of Clinical Nutrition   Check publisher's open access policy
ISSN 1938-3207
0002-9165
Publication date 2016-01-01
Year available 2015
Sub-type Article (original research)
DOI 10.3945/​ajcn.115.115477
Volume 103
Issue 1
Start page 283
End page 289
Total pages 7
Place of publication Bethesda, MD, United States
Publisher American Society for Nutrition
Language eng
Formatted abstract
Background: There is evidence that renal transplant recipients have accelerated atherosclerosis that is manifest by increased cardiovascular morbidity and mortality. The high incidence of atherosclerosis is, in part, related to increased arterial stiffness, vascular dysfunction, elevated oxidative stress, and inflammation associated with immunosuppressive therapy. The carotenoid astaxanthin has shown potent antioxidant and anti-inflammatory properties.

Objective: The aim was to investigate the effects of oral astaxanthin on arterial stiffness, oxidative stress, and inflammation in renal transplant recipients.

Design: This trial used a randomized, placebo-controlled, double-blind design in which 61 patients received either 12 mg astaxanthin/d or an identical placebo orally for 1 y. Primary outcomes were 1) arterial stiffness measured by aortic pulse wave velocity (PWV), 2) oxidative stress assessed by total plasma F2-isoprostanes, and 3) inflammation assessed by plasma pentraxin-3. Secondary outcomes included vascular function, carotid artery intima-media thickness, augmentation index, central blood pressure, subendocardial viability ratio, and additional measures of oxidative stress and inflammation. Patients underwent assessments at baseline and at 6 and 12 mo.

Results: Fifty-eight participants completed the study. There were no significant between-group differences in the changes in any of the primary outcome measures (PWV changed by +9.5% and +6.0%, F2-isoprostanes changed by −3.0% and −9.7%, and pentraxin-3 changed by +50.6% and −11.0% in the placebo and astaxanthin groups, respectively). There were no significant between-group differences in secondary outcome measures. Larger-than-expected variability decreased the power of the study and increased the possibility of a type 2 statistical error.

Conclusion: Astaxanthin (12 mg/d for 12 mo) had no effect on arterial stiffness, oxidative stress, or inflammation in renal transplant recipients. This trial was registered at the Australian New Zealand Clinical Trials Registry (http://www.anzctr.org.au/) as ACTRN12608000159358.
Keyword Carotid artery intima-media thickness
F2-isoprostanes
Pentraxin-3
Pulse wave velocity
Vascular function
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ
Additional Notes Published online 16 December 2015

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2016 Collection
School of Human Movement and Nutrition Sciences Publications
School of Medicine Publications
 
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Created: Mon, 18 Jan 2016, 20:01:21 EST by Sandrine Ducrot on behalf of School of Human Movement and Nutrition Sciences